PMID: 9533773Apr 9, 1998Paper

Detection of a potential receptor for the H-blood-group antigen on rat colon-carcinoma cells and normal tissues

International Journal of Cancer. Journal International Du Cancer
O GalaninaJ Le Pendu

Abstract

Up-regulation of the synthesis of carbohydrate tumor-associated antigens terminated by the disaccharide Fucalpha1-2Gal is frequent in colon carcinoma and associated with poor prognosis. There is evidence that Fucalpha1-2Gal (H-disaccharide) structures increase cancer-cell motility and tumorigenicity by as-yet unknown mechanisms. Using polyacrylamide-based neoglycoconjugates, we looked for a potential receptor for this disaccharide, and observed that a neoglycoconjugate probe containing the H-disaccharide could bind rat colon-carcinoma cells in a dose-dependent manner, whereas very little binding was evidenced when a probe containing glucose was used. Binding of the H-disaccharide probe could be inhibited by the free H-disaccharide as well as by unlabeled neoglycoconjugates containing a terminal H-disaccharide. The best inhibitor was the H-type-1 trisaccharide neoglycoconjugate. Histochemical detection of the potential H-receptor was performed on rat normal tissues and in situ 1,2-dimethylhydrazine-induced colon carcinomas. A strong binding of the H-disaccharide probe was evidenced on most tumors that could be partly inhibited by the trisaccharide Fucalpha1-2Galbeta1-4Glc and by the unlabeled H-disaccharide neoglycoconjugate, in...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·R ZennadiJ Le Pendu
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·A CaignardF Martin
Jan 1, 1980·Advances in Cancer Research·E Farber, R Cameron
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·J SunM Blaszczyk-Thurin
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M M LotzA M Mercurio
Feb 1, 1997·Glycoconjugate Journal·P Greenwell

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Citations

Feb 1, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Steven E DominoElizabeth A Hurd
Sep 22, 2011·Expert Opinion on Drug Delivery·Mayur M Patel
Mar 17, 2009·Acta histochemica·Olga KurmyshkinaNicolai Bovin
Jan 12, 1999·Analytical Biochemistry·O E GalaninaN V Bovin

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