Detection of a t(8;21)(q22;q22) in a case of M5 acute monoblastic leukemia

Cancer Genetics and Cytogenetics
M T MoleroJ J Malcorra

Abstract

Although the translocation (8;21) is the single most common structural rearrangement reported in acute myeloblastic leukemia (AML), it is rarely seen in AML FAB type M5. We describe a case of a 51-year-old male with a diagnosis of acute monoblastic leukemia (AML M5b with hemophagocytic component) whose karyotype showed at (8;21)(q22;22). To our knowledge, this is the first report of this translocation in an AML M5b. The t(8;21) has been associated with a good prognosis, but our patient suffered a fast and fatal evolution.

References

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Citations

Mar 20, 2003·Cancer Investigation·Joäelle MichaudRobert Escher
Aug 17, 2006·Journal of Pediatric Hematology/oncology·Tamar TadmorDina Attias
Jun 11, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Christine GarciaKaaren K Reichard

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