Detection of activated leukocyte cell adhesion molecule in the serum of breast cancer patients and implications for prognosis

Oncology
Isabell WitzelKarin Milde-Langosch

Abstract

Conflicting results have been reported about activated leukocyte cell adhesion molecule (ALCAM) expression in breast cancer and its prognostic value. Little is known about the role of ALCAM levels in the serum of breast cancer patients. We analyzed soluble ALCAM (sALCAM) levels in the serum of 157 primary breast cancer patients and 48 healthy women by ELISA. In addition, we determined ALCAM protein expression by Western blot analysis (n = 120) and mRNA expression by cDNA microarray analysis (n = 115) in the tumor tissue of corresponding patients. sALCAM levels differed between patients and healthy controls (median 24.2 vs. 18.9 ng/ml, p < 0.001). We observed no correlation between serum levels and protein or mRNA expression in corresponding tumors (r < 0.1, p = n.s.). sALCAM levels were not correlated with histological type, grading, tumor stage, or patient age, but elevated sALCAM levels were associated with shorter disease-free survival (HR = 1.97, 95% CI 1.01-3.2, p = 0.043). Our results indicate that sALCAM can be detected in the serum of patients with primary breast cancer. Elevated serum levels might indicate more aggressive tumor behavior as they might be an independent factor for a worse prognosis in breast cancer patie...Continue Reading

References

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Jul 14, 2010·Breast Cancer Research and Treatment·Isabell WitzelVolkmar Müller
Mar 3, 2011·PloS One·Francesca MiccichèItalia Bongarzone

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Citations

May 11, 2012·Experimental & Molecular Medicine·Chun Hua Wei, Seong Eon Ryu
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kayhan ErturkBurak Sakar
Nov 22, 2012·International Journal of Cancer. Journal International Du Cancer·Grazia CarbottiMarina Fabbi
Mar 1, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Leila EskandariMohammad Rahmati-Yamchi
Jul 12, 2016·Expert Review of Molecular Diagnostics·Meng XiaoWantao Chen
Dec 10, 2014·The Journal of Cell Biology·Miklós Müller, Caitlin Sedwick
Mar 30, 2013·Cancer Research·Amanda G HansenAndries Zijlstra
Jul 18, 2021·Cytokine & Growth Factor Reviews·Fátima FerragutMaría T Elola

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