PMID: 8937902Nov 1, 1996Paper

Detection of aldehydes in bronchoalveolar lavage of rats exposed to ozone

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
W A PryorG L Squadrito

Abstract

We report the detection of hexanal, heptanal, and nonanal in the bronchoalveolar lavage (BAL) of rats exposed to 0.5 to 10 ppm ozone with or without simultaneous 5% CO2. These three aldehydes primarily result from the Criegee ozonation of specific mono- or polyunsaturated fatty acids that are present in significant amounts in the rat lung; e.g., palmitoleic acid gives heptanal, oleic gives nonanal, and linoleic and arachidonic can give hexanal. Hexanal also is produced in the ozone-initiated autoxidation of any n-6 polyunsaturated fatty acid, and thus is a measure of generalized oxidative stress. (Monounsaturated fatty acids do not undergo appreciable autoxidation.) This detection and quantitation of aldehydes directly demonstrates for the first time that unsaturated fatty acids undergo Criegee ozonation in the lung when ozone is inhaled. Exposure to ozone alone produced smaller apparent yields of the three aldehydes than did exposure to ozone plus 5% CO2. Hexanal, heptanal, and nonanal can be detected in BAL of rats 5 hr after the end of the ozone exposure, but after more than 5 hr only hexanal can be found, probably from ozone-induced autoxidation of n-6 PUFA that continues after ozone exposure. The measured amounts of aldehy...Continue Reading

Citations

Jan 16, 1999·Free Radical Biology & Medicine·L L de ZwartN P Vermeulen
Jul 13, 1999·Free Radical Biology & Medicine·M C MaddenA J Ghio
Mar 3, 2007·The Journal of Clinical Investigation·Edward M Postlethwait
May 1, 2009·Journal of Translational Medicine·Hye-Won ShinDan M Cooper
Oct 24, 2001·Environmental Health Perspectives·C K WilkinsG D Nielsen
Oct 28, 1998·Environmental Health Perspectives·C E CrossB Halliwell
Jan 15, 2005·Free Radical Biology & Medicine·Carol A BallingerEdward M Postlethwait
Nov 12, 2015·Biomolecules·Muna Sapkota, Todd A Wyatt
Jun 26, 2012·Toxicology and Applied Pharmacology·Vasanthi R SunilDebra L Laskin
Apr 1, 2010·Journal of the Science of Food and Agriculture·Herbert FuhrmannPeggy Braun
Sep 18, 2015·Particle and Fibre Toxicology·Prem KumarathasanRenaud Vincent
Jun 11, 1999·Environmental Research·E BermúdezM G Mustafa
Jul 7, 1998·Toxicology and Applied Pharmacology·R M KafouryM Friedman
May 28, 2020·Critical Reviews in Toxicology·Sonika Patial, Yogesh Saini
Jun 25, 1998·The American Journal of Physiology·E M PostlethwaitW A Pryor
Jan 1, 2002·Toxicology Mechanisms and Methods·Prem KumarathasanJosée Guénette
Nov 2, 2002·American Journal of Respiratory and Critical Care Medicine·Massimo CorradiEugenio Baraldi
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·M W FramptonM J Utell
Jun 8, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Giuseppe L SquadritoSadis Matalon
Jul 21, 1999·Human & Experimental Toxicology·G D NielsenY Alarie
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·R M KafouryM Friedman
Oct 5, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Katherine C ThompsonArwel V Hughes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved