Detection of amastigotes of Trypanosoma cruzi in a kidney graft with acute dysfunction

Transplantation Proceedings
L F AriasM Arbeláez

Abstract

We described a case of allograft kidney dysfunction associated with renal parenchymal infection with amastigotes of Trypanosoma cruzi. The patient was diagnosed as being chronically infected prior to transplantation. The infection was probably acquired by blood transfusion. He could not complete antiparasitic treatment due to drug toxicity. He was transplanted from a cadaver who showed a negative test for Chagas' disease. One year after transplantation the serum creatinine progressively increased. Histological examination of renal biopsy revealed intracytoplasmic amastigotes of T cruzi. No evidence of other specific alterations in the graft was detected. It was unknown whether graft dysfunction was only due to parasitic infection. The present case confirmed that T cruzi can infect kidney grafts and that immunosuppression in kidney transplantation is potentially a cause of dissemination of Chagas' disease.

References

Jul 1, 1997·Revista Do Instituto De Medicina Tropical De São Paulo·M F CarvalhoV A Soares
Oct 26, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A RiarteM Vázquez

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Citations

Sep 29, 2009·Parasitology Research·Gabriel Melo de OliveiraNestor Schor
Feb 18, 2011·Parasitology Research·Gabriel M de OliveiraNestor Schor
May 30, 2013·Infectious Disease Clinics of North America·Laura O'Bryan Coster
May 15, 2010·Infectious Disease Clinics of North America·Patricia MuñozEmilio Bouza
May 11, 2012·Transfusion·Teresa Jimenez-MarcoEnrique Girona-Llobera
Apr 11, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C KocherN J Mueller
Jan 22, 2010·Clinical Transplantation·Fernando BacalEdimar Alcides Bocchi
Aug 4, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Carlos Franco-ParedesAngela M Caliendo
Aug 21, 2013·PloS One·Juliana Regina Dias LemosJavier Emilio Lazo Chica
Jun 12, 2012·Journal of Advanced Nursing·Melanie D Logue, Judith A Effken
Apr 25, 2014·Asian Journal of Andrology·Roxanne Wadia, Daniel P Petrylak
May 17, 2014·Asian Journal of Andrology·Min QuYing-Hao Sun

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