Detection of an avian lineage influenza A(H7N2) virus in air and surface samples at a New York City feline quarantine facility

Influenza and Other Respiratory Viruses
Francoise M BlachereJohn D Noti

Abstract

In December 2016, an outbreak of low pathogenicity avian influenza (LPAI) A(H7N2) occurred in cats at a New York City animal shelter and quickly spread to other shelters in New York and Pennsylvania. The A(H7N2) virus also spread to an attending veterinarian. In response, 500 cats were transferred from these shelters to a temporary quarantine facility for continued monitoring and treatment. The objective of this study was to assess the occupational risk of A(H7N2) exposure among emergency response workers at the feline quarantine facility. Aerosol and surface samples were collected from inside and outside the isolation zones of the quarantine facility. Samples were screened for A(H7N2) by quantitative RT-PCR and analyzed in embryonated chicken eggs for infectious virus. H7N2 virus was detected by RT-PCR in 28 of 29 aerosol samples collected in the high-risk isolation (hot) zone with 70.9% on particles with aerodynamic diameters >4 μm, 27.7% in 1-4 μm, and 1.4% in <1 μm. Seventeen of 22 surface samples from the high-risk isolation zone were also H7N2 positive with an average M1 copy number of 1.3 × 103 . Passage of aerosol and surface samples in eggs confirmed that infectious virus was present throughout the high-risk zones in t...Continue Reading

References

Jan 13, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Francoise M BlachereDonald H Beezhold
Jun 15, 2011·Journal of Virological Methods·Francoise M BlachereDonald H Beezhold
Aug 27, 2013·Acta Veterinaria Hungarica·Heng WangZhangyong Ning
Jun 13, 2014·Journal of Virology·Jessica A BelserTerrence M Tumpey
Feb 1, 2017·The Journal of Hospital Infection·K-A Thompson, A M Bennett
Jun 10, 2017·Genome Announcements·Sandra P NewburyKathy Toohey-Kurth
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher T LeeUNKNOWN Influenza A(H7N2) Response Team
Nov 18, 2017·Emerging Infectious Diseases·Atanaska Marinova-PetkovaC Todd Davis
Dec 8, 2017·MMWR. Morbidity and Mortality Weekly Report·Vivien G DuganDaniel Jernigan
Dec 21, 2017·Emerging Infectious Diseases·Masato HattaYoshihiro Kawaoka

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Citations

Oct 23, 2019·Journal of Occupational and Environmental Hygiene·William G LindsleyJohn D Noti
Aug 20, 2020·Transboundary and Emerging Diseases·Gonzalo López-LorenzoGonzalo Fernández
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Brian R WasikColin R Parrish
Aug 29, 2021·Viruses·Tadeusz FrymusMargaret J Hosie

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Methods Mentioned

BETA
PCR
BioSamplers
BioSampler

Software Mentioned

Primer Express

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