PMID: 7008712Feb 1, 1981Paper

Detection of anti-dsDNA as diagnostic tool

Annals of the Rheumatic Diseases
A J SwaakT E Feltkamp

Abstract

The diagnostic significance of anti-dsDNA determinations was evaluated in 2 different groups of patients. When the immunofluorescence technique (IFT) with Crithidia luciliae and the Farr assay with 3H-labelled-PM2 DNA were applied to a selected panel of 536 sera from patients with various well-defined autoimmune diseases, positive results were obtained only with serum samples from patients with systemic lupus erythematosus (SLE). On the other hand when we screened 4431 sera sent to our laboratory for diagnostic reasons, we observed a high incidence of antibodies to dsDNA in patients who did not fulfil the preliminary American Rheumatism Association's criteria for SLE and did not have the diagnosis SLE. Furthermore, a significant number of the positive sera showed peculiar behaviour in that they were positive only in the IFT on Crithidia luciliae and not in the Farr assay.

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Citations

Nov 1, 1992·Molecular Biology Reports·R Smeenk, M Hylkema
Dec 30, 1982·Journal of Immunological Methods·R SmeenkL Aarden
Jan 1, 1991·Molecular Aspects of Medicine·S BlountJ Lunec
May 1, 1993·Free Radical Biology & Medicine·K FrenkelE Taioli
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M J ShlomchikM G Weigert
Jun 1, 1987·Annals of the Rheumatic Diseases·D A IsenbergA Todd-Pokropek
Mar 1, 1984·Journal of Clinical Pathology·D J LeaD J Ward
Apr 1, 1985·The Journal of Clinical Investigation·R A EisenbergW J Yount
Mar 1, 1990·Clinical Rheumatology·R SmeenkT Swaak
Jan 1, 1991·Rheumatology International·R J SmeenkA J Swaak
Jan 1, 1985·Scandinavian Journal of Rheumatology·T K Lee, H Rothberger
Jan 1, 1985·Scandinavian Journal of Rheumatology. Supplement·R SmeenkT Swaak
Jan 1, 1985·Scandinavian Journal of Rheumatology. Supplement·L AardenR Smeenk
Mar 1, 1984·Journal of Clinical Pathology·C D Ribeiro, P A Jenkins
Mar 1, 1984·Journal of Clinical Pathology·R Maskell
Aug 1, 1997·Kidney International·J H Berden

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