PMID: 2504235May 1, 1989Paper

Detection of anti-HIV immunoglobulin M by particle agglutination following acute HIV infection

AIDS
D S HealeyI D Gust

Abstract

In a study of 23 subjects infected with HIV, a modified particle agglutination assay was used to detect anti-HIV-specific immunoglobulin M (IgM). The presence of anti-HIV IgM was demonstrated in every subject, becoming detectable 1-2 weeks after the onset of acute symptoms, and showing a variable duration of 1-5 weeks. Anti-HIV immunoglobulin G (IgG) developed 1-2 weeks after anti-HIV IgM. Particle agglutination detected the presence of specific antibody up to 7-10 days earlier than the Abbott recombinant or Genetic Systems enzyme immunoassays. In this study, all subjects with acute infection became clearly positive by Western blot within 3 months of the onset of acute symptoms.

Citations

Jan 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M C ReM La Placa
May 15, 2002·Journal of Virological Methods·Maria MakuwaFrançois Simon
May 1, 1996·Health Care for Women International·L MoneyhamJ Guillory
Oct 1, 1991·Genitourinary Medicine·M D de JongJ M Lange

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