Detection of antibodies against phenolic glycolipid-1 (PGL-1), 35-kDa and 30-40-kDa components of Mycobacterium leprae in the cerebrospinal fluid of of leprosy patients

Journal of Medical Microbiology
S A PatilU Sengupta

Abstract

The involvement of the central nervous system (CNS) in lepromatous leprosy (LL) patients was investigated; 33 patients were examined clinically in detail and upper motor neuron involvement was observed in eight and lower motor neuron in three of these patients. Anti-Mycobacterium leprae antibodies could be detected in the CSF by PGL-1 enzyme-linked immunosorbent assay (ELISA) and monoclonal antibody (MAb) based competitive assays against defined epitopes on the 35-kDa protein and 30-40-kDa polysaccharide (lipoarabinomannan) antigens with MAbs MLO4 and ML34, respectively. Antibodies against PGL-1 and 35-kDa protein were observed in more subjects than antibodies against the 30-40-kDa antigen. Some correlation was observed between the upper motor neuron signs and antibody positivity for 35-kDa and PGL-1 antigens in the CSF of these patients.

Citations

Feb 18, 2014·Journal of Neurosurgery·Kyung-Hwa LeeShin Jung
Apr 7, 2007·Journal of Neuropathology and Experimental Neurology·Thida AungMasamichi Goto
Nov 11, 2016·Acta neurochirurgica·Divyam SharmaShrey Jain
Jan 11, 2013·Memórias do Instituto Oswaldo Cruz·Isabel BaezaIris Estrada-Garcia
Feb 15, 2019·The American Journal of Tropical Medicine and Hygiene·Kiran PolavarapuAtchayaram Nalini
Mar 15, 2016·International Journal of Mycobacteriology·Shripad PatilKavitha Kumar

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