PMID: 8608687Nov 1, 1995Paper

Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase

Clinical Rheumatology
M MiyataR Kasukawa

Abstract

The antibody to 65 KD mycobacterial heat shock protein (HSP65) and antibody to human superoxide dismutase (H-SOD) were measured by ELISA in patients with autoimmune hepatitis (AIH), and results were compared with those of patients with chronic active hepatitis C (CAH-C) or systemic lupus erythematosus (SLE) and normal subjects (NS). Patients with AIH had significantly higher OD values of anti-HSP65 antibody and anti-H-SOD antibody compared with those of patients with CAH-C or SLE and NS. OD values of anti-HSP65 antibody were correlated with those of anti-SOD antibody. Affinity-purified anti-SOD antibody reacted with HSP65. Analysis of the amino acid sequence of human SOD showed that 7 segments, corresponding to r to 25 amino acid residues, exhibited 50 to 71% homology with that of my mycobacterial HSP65.

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Citations

Jan 5, 2008·Neurological Research·Javier Vaquero, Roger F Butterworth
Apr 17, 2004·The Journal of Investigative Dermatology·Masaki NagaiShinichi Sato
Sep 10, 2011·Medical Hypotheses·Coad Thomas Dow
Mar 20, 2015·Frontiers in Immunology·Leonardo A Sechi, Coad Thomas Dow
Jun 13, 2006·Proteomics·Motonari TakashimaKazuyuki Nakamura
Oct 2, 2004·Clinical Rheumatology·Meenakshi Jolly, J J Curran
Mar 8, 2008·Autoimmunity·M Zouhair Atassi, Paolo Casali
Aug 1, 2013·Auto- Immunity Highlights·Takashi Himoto, Mikio Nishioka
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Palazzo FiorentinaGiulietta Minozzi

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