Detection of antibodies to both M. leprae PGL-I and MMP-II to recognize leprosy patients at an early stage of disease progression

Diagnostic Microbiology and Infectious Disease
Hongsheng WangMasahiko Makino

Abstract

Antibodies to phenolic glycolipid (PGL)-I and major membrane protein (MMP)-II were evaluated for serodiagnosis of leprosy in Southwest China, and the role in predicting the occurrence of the disease in household contacts (HHCs) of leprosy was examined. Using PGL-I (natural disaccharide-octyl-bovine serum albumin) antigen-based diagnosis (IgM antibodies), we could detect 94.9% of multibacillary (MB) leprosy and 38.9% paucibacillary (PB) leprosy patients, whereas using MMP-II (IgG antibody), 88.1% of MB and 61.1% of PB patients were positive. By combining the 2 tests and considering either test positive as positive, 100% of MB patients and 72.2% of PB patients were found to test positive. Of the HHCs of leprosy, 28.3% and 30% had positive levels of PGL-I and MMP-II Abs, respectively. Seven out of 21 HHCs, who had high Ab titer to either antigen, developed leprosy during the follow-up period of 3 years. These data suggest that the measurement of both anti-PGL-I as well as anti-MMP-II antibodies could facilitate early detection of leprosy.

References

Apr 11, 2001·QJM : Monthly Journal of the Association of Physicians·D N Lockwood, A J Reid
Apr 23, 2005·Infection and Immunity·Yumi MaedaMasahiko Makino
Sep 15, 2006·Scandinavian Journal of Immunology·O ParkashT H M Ottenhoff
May 25, 2007·FEMS Microbiology Letters·Yumi MaedaMasahiko Makino
Feb 21, 2009·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Koichi SuzukiNorihisa Ishii

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