PMID: 7545211Apr 1, 1995Paper

Detection of antibodies to L1, L2, and E4 proteins of human papillomavirus types 6, 11, and 16 by ELISA using synthetic peptides

Journal of Medical Virology
P Le CannP Coursaget

Abstract

Antibodies against eight synthetic peptides spanning different epitopes located on L1, L2, and E4 proteins of human papillomavirus (HPV) types 16, 6, and 11 were examined in sera from 73 women infected by HPV and from 139 healthy controls. Only three of these peptides were reactive. Two located on proteins L2 and E4 of HPV 16 seem type specific since antibodies to these peptides were detected, respectively, in 21% and 15% of the HPV 16 infected patients and in 2.5% and none of women infected by other HPVs. The third peptide located on the L1 protein of HPV 6 bears a common epitope since antibodies to this peptide were detected not only in 85% of women infected by HPV 6 or 11, but also in 82% of women infected by other HPVs, and in 74% and 71% of the control groups (10-12-year-old children and adults, respectively). In conclusion, none of the peptides investigated seems useful to develop ELISAs for serological diagnosis of HPV infection.

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Citations

Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M E ScheurerK Adler-Storthz
Apr 1, 1997·Postgraduate Medical Journal·S Janmohamed, S R Bloom
Jul 6, 2010·Protein Expression and Purification·Alicia Fernández-San MillánJosé M Escribano
Oct 25, 2016·Autoimmunity Reviews·Darja Kanduc, Yehuda Shoenfeld
Aug 28, 2020·International Reviews of Immunology·Babban JeeShivendra Kumar Shahi

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