PMID: 9658433Jul 11, 1998Paper

Detection of antiphospholipid antibodies in children and adolescents

Pediatric Hematology and Oncology
C KratzU Göbel

Abstract

The prevalence of antiphospholipid antibodies (APAs) has not yet been studied in children and adolescents with various diseases. We assayed plasma samples of 203 children and adolescents, aged 0.1 to 21 years (median 6 years), by enzyme-linked immunosorbent assay detecting immunoglobulin G (IgG) and IgM antibodies directed against cardiolipin, phosphatidylserine, and phosphatidic acid. According to their diagnosis children were divided into five groups: 10 patients with autoimmune and autoimmune-like diseases (group I); 88 patients with infections (group II); 20 patients with metabolic diseases (group III); 65 children with various other diseases (group IV); 20 healthy children without physical illnes (group V). Results were compared for statistical significance using Fisher's exact test. APAs were found in 65 of 203 patients. In all groups of patients the prevalence of APAs was increased compared with healthy children. The highest prevalence of APAs was found in patients with autoimmune or autoimmune-like diseases or infections. Thrombosis did not occur in children with increased APA levels. In 4 of 65 patients with detectable APAs bleeding was observed. However, three of these four children had additional coagulation abnormal...Continue Reading

References

Sep 1, 1991·Annals of the Rheumatic Diseases·R CaporaliA Martini
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J Rauch, A S Janoff
Jan 1, 1990·British Journal of Haematology·E N Harris
Oct 1, 1986·Clinical Immunology and Immunopathology·O VaaralaK Aho
Mar 1, 1980·The Journal of Pediatrics·G M BrodeurJ A Willimas
Jul 1, 1994·European Journal of Pediatrics·A RavelliG R Burgio
Apr 1, 1994·Archives of Pediatrics & Adolescent Medicine·A RavelliA Martini

❮ Previous
Next ❯

Citations

Apr 12, 2003·Progress in Lipid Research·John A McIntyreW Page Faulk
Jun 11, 2002·Journal of Interventional Cardiology·G Hausdorf
May 29, 2007·Current Rheumatology Reports·Tadej Avcin, Natasa Toplak
Aug 2, 2006·Rheumatic Diseases Clinics of North America·Rolando Cimaz, Elodie Descloux
Oct 25, 2016·Indian Pediatrics·Kim VaipheiAnju Gupta
Jul 30, 2019·Frontiers in Immunology·Anush MartirosyanGayane Manukyan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Related Papers

Seminars in Thrombosis and Hemostasis
M J Manco-Johnson
BMJ : British Medical Journal
A W Joss, M M Steven
Annals of the Rheumatic Diseases
D A Isenberg
© 2022 Meta ULC. All rights reserved