Detection of apoptosis during orthodontic tooth movement in rats

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
M W RanaX M Xu

Abstract

Experimental evidence suggests that cellular changes and tissue turnover occurs in the periapical tissue during tooth movement. The possible role of apoptosis in tooth movement has never been investigated. The purpose of this study was to show whether apoptosis plays any role in orthodontic tooth movement. A sample of 21 adult male Sprague-Dawley rats was divided into 4 groups. Orthodontic appliances were attached to the rats for various times-to group I (n = 6) for 3 days, to group II (n = 6) for 1 week, and to group III (n = 6) for 2 weeks. Rats in group IV (n = 3) had appliances but no force and served as the control group. At the end of the observation period, the animals were killed and tissue blocks of involved teeth were processed and prepared for TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) reaction. TUNEL-positive cells from selected areas on each slide were counted and compared by means of an analysis of variance. Group I demonstrated a significantly higher (P <.05) number of positive cells. This suggests that the maximum apoptosis occurs approximately 3 days after the application of the appliance.

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Citations

Apr 19, 2003·International Endodontic Journal·P G SatchellD E Witherspoon
Oct 27, 2009·The Angle Orthodontist·Rita VeberieneVita Machiulskiene
Oct 27, 2009·The Angle Orthodontist·Angelo LeoneMaria Buscemi
Jan 14, 2004·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Giuseppe PerinettiPaola Esposito
Mar 6, 2013·Orthodontics & Craniofacial Research·F L WeiC L Wang
Nov 19, 2010·European Journal of Oral Sciences·Polbhat TripuwabhrutSivakami Rethnam
Jul 23, 2011·Journal of Periodontal Research·C XuF Zhang
Feb 20, 2016·Clinical Oral Investigations·Katja KorbRalf Erber
Feb 25, 2006·Journal of Dental Research·Y GogaH Mitani
Jan 12, 2020·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·S KayaG Işık
Jul 14, 2018·Korean Journal of Orthodontics·Yukari MinatoKazutaka Kasai
Oct 29, 2003·The Journal of Biological Chemistry·Xiaozhe Han, Salomon Amar
Nov 6, 2002·Journal of Biomedical Materials Research·Chia-Tze KaoTsui-Hsien Huang
Oct 26, 2014·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Katja DierckeRalf Erber

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis