PMID: 8584226Oct 13, 1995Paper

Detection of apoptosis in weaver cerebellum by electron microscopic in situ end-labeling of fragmented DNA

Neuroscience Letters
A MigheliB Ghetti

Abstract

Massive degeneration of granule cell precursors occurs perinatally in the cerebellum of weaver mutant mice. We have studied the electron microscopic (EM) features of granule cell death in weaver and control mice, using an in situ end-labeling (ISEL) technique for detecting DNA fragmentation, a hallmark of apoptosis. In all animals, EM-ISEL revealed the pattern of apoptosis, with an enhanced expression in weaver mice. The weaver gene appears to accelerate the death program, most likely through potassium channel-mediated signals.

References

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Citations

Mar 9, 2002·Biochemical and Biophysical Research Communications·Shiro SudaNobufumi Kawai
Nov 17, 2004·Neurotoxicity Research·Francis C LauLouise C Abbott
Aug 23, 2006·Experimental Brain Research·Jinglu AiAndrew J Baker
Dec 20, 2005·The Journal of Membrane Biology·F LangS M Huber
Mar 6, 2009·Journal of Neural Transmission·Konstantinos SpiliopoulosAda Mitsacos
Jul 10, 2003·Gastroenterology·Roberto De GiorgioRoberto Corinaldesi
Jun 6, 2003·Progress in Neurobiology·L Lossi, A Merighi
Dec 3, 2005·The Cerebellum·Rebecca M SavillBeth Coyle
Mar 5, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Claudia CastagnaLaura Lossi
Apr 29, 1998·Developmental Biology·S M Harrison, S K Roffler-Tarlov
Jul 5, 2005·The Veterinary Journal·L LossiA Merighi
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·H D'ArceuilF G Blankenberg
Jan 1, 2014·Cerebellum & Ataxias·Jan Cendelin
Dec 18, 2015·Physiological Research·F VoŽeh
Aug 25, 2004·The International Journal of Biochemistry & Cell Biology·Pawel P LiberskiPaul Brown
Feb 24, 2007·Archives of Biochemistry and Biophysics·Florian LangErich Gulbins

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis