Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples

Analytical and Bioanalytical Chemistry
Anjali KumariSylvia Daunert

Abstract

Bacteria communicate among themselves using certain chemical signaling molecules. These signaling molecules generally are N-acyl homoserine lactones (AHLs) in Gram-negative bacteria and oligopeptides in Gram-positive bacteria. In addition, both Gram-positive and Gram-negative bacteria produce a family of signaling molecules known as autoinducer-2 that they employ for their communications. Bacteria coordinate their behavior by releasing and responding to the chemical signaling molecules present in proportion to their population density. This phenomenon is known as quorum sensing. The role of bacteria in the pathogenesis of several diseases, including gastrointestinal (GI) disorders, is well established. Moreover, rather recently bacterial quorum sensing has been implicated in the onset of bacterial pathogenicity. Thus, we hypothesized that the signaling molecules involved in bacterial communication may serve as potential biomarkers for the diagnosis and management of several bacteria-related diseases. For that, we previously developed a method based on genetically engineered whole-cell sensing systems for the rapid, sensitive, cost-effective and quantitative detection of AHLs in biological samples, such as saliva and stool, from...Continue Reading

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Citations

Feb 4, 2010·Inflammatory Bowel Diseases·Giulia RodaAldo Roda
Feb 1, 2012·Analytical and Bioanalytical Chemistry·Anjali K StrussSylvia Daunert
Sep 19, 2012·Analytical and Bioanalytical Chemistry·Tommaso R I CataldiPhilippe Schmitt-Kopplin
Apr 28, 2011·Microbial Ecology·Karina GolbergAriel Kushmaro
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Oct 5, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Maggie HicksBaojun Wang
Apr 8, 2015·Biopolymers·Evelien WynendaeleBart De Spiegeleer
Aug 5, 2017·Microbial Biotechnology·Hung-Ju ChangJérôme Bonnet
Apr 28, 2017·Frontiers in Neuroscience·Frederick VerbekeBart De Spiegeleer
Jan 8, 2020·Microorganisms·Sebastián Acosta-JuradoFrancisco Pérez-Montaño
Jun 8, 2021·Biosensors & Bioelectronics·Michael MoraskieSylvia Daunert
May 2, 2020·ACS Chemical Biology·Shi-Hui DongSatish K Nair
Feb 12, 2019·Analytical Chemistry·Alda Diaz PerezJulie A Stenken
Dec 21, 2021·Frontiers in Bioengineering and Biotechnology·Sahana VasudevanAdline Princy Solomon

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