Detection of "bath salts" and other novel psychoactive substances in hair samples of ecstasy/MDMA/"Molly" users

Drug and Alcohol Dependence
Joseph J PalamarCharles M Cleland

Abstract

Ecstasy (MDMA) in the US is commonly adulterated with other drugs, but research has not focused on purity of ecstasy since the phenomenon of "Molly" (ecstasy marketed as pure MDMA) arose in the US. We piloted a rapid electronic survey in 2015 to assess use of novel psychoactive substances (NPS) and other drugs among 679 nightclub/festival-attending young adults (age 18-25) in New York City. A quarter (26.1%) of the sample provided a hair sample to be analyzed for the presence of select synthetic cathinones ("bath salts") and some other NPS. Samples were analyzed using fully validated UHPLC-MS/MS methods. To examine consistency of self-report, analyses focused on the 48 participants with an analyzable hair sample who reported lifetime ecstasy/MDMA/Molly use. Half (50.0%) of the hair samples contained MDMA, 47.9% contained butylone, and 10.4% contained methylone. Of those who reported no lifetime use of "bath salts", stimulant NPS, or unknown pills or powders, about four out of ten (41.2%) tested positive for butylone, methylone, alpha-PVP, 5/6-APB, or 4-FA. Racial minorities were more likely to test positive for butylone or test positive for NPS after reporting no lifetime use. Frequent nightclub/festival attendance was the stro...Continue Reading

References

Nov 1, 2000·JAMA : the Journal of the American Medical Association·M BaggottJ Zehnder
Feb 20, 2002·British Journal of Clinical Pharmacology·Jonathan McCormick
Dec 21, 2005·Drug and Alcohol Dependence·Emily E Tanner-Smith
Aug 29, 2006·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Brian C KellyBrooke E Wells
Oct 7, 2009·Addiction·Neeltje VogelsRaymond J M Niesink
Aug 21, 2010·Emergency Medicine Journal : EMJ·David Michael WoodJohn Ramsey
Aug 26, 2010·Addiction·Adam R WinstockFabrizio Schifano
Sep 10, 2010·Journal of Psychopharmacology·Tibor M BruntWim van den Brink
Jan 5, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alvin C BronsteinSandra L Giffin
Mar 23, 2011·Drug and Alcohol Dependence·R L Carhart-HarrisD J Nutt
Jan 3, 2012·Drug and Alcohol Dependence·Raimondo BrunoNatasha Sindicich
Apr 24, 2012·Drug Testing and Analysis·Kristina Yasmin RustThomas Kraemer
May 26, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·D Di CorciaM Vincenti
May 15, 2013·Therapeutic Drug Monitoring·Pascal Kintz
Jul 25, 2013·Human Psychopharmacology·Máté Kapitány-FövényZsolt Demetrovics
Jul 25, 2013·Human Psychopharmacology·Fernando Caudevilla-GálligoIván Fornís
Jul 31, 2013·Forensic Science International : Synergy·Jolanta B Zawilska, Jakub Wojcieszak
Aug 7, 2013·Drug and Alcohol Dependence·Karen MiottoChristine Wang
Jan 7, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·James B MowryMarsha Ford
May 26, 2015·Drug and Alcohol Dependence·Joseph J PalamarDanielle C Ompad
Oct 21, 2015·Drug and Alcohol Dependence·Jolanta B Zawilska, Dariusz Andrzejczak
Dec 19, 2015·Analytical and Bioanalytical Chemistry·Alberto SalomoneMarco Vincenti

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Citations

Jun 15, 2016·Drug and Alcohol Dependence·Joseph J PalamarCharles M Cleland
Nov 3, 2016·The American Journal of Drug and Alcohol Abuse·Joseph J PalamarCharles M Cleland
Jul 16, 2016·The American Journal on Addictions·Joseph J PalamarAdam R Winstock
Dec 8, 2016·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Joseph J Palamar
Feb 16, 2017·Journal of Psychopharmacology·Vincent D PisanoSelma C Holden
Mar 14, 2018·Journal of Addiction Medicine·Elon E RichmanRobert O Cotes
Sep 12, 2018·Journal of Psychoactive Drugs·Joseph J Palamar
Oct 30, 2018·Journal of Analytical Toxicology·Alex J KrotulskiBarry K Logan
Jan 3, 2019·The American Journal of Drug and Alcohol Abuse·Joseph J PalamarBabak Tofighi
Nov 22, 2018·Journal of Analytical Toxicology·Alberto SalomoneMarco Vincenti
Oct 20, 2018·Psychopharmacology·Chicora F OliverScott M Rawls
Sep 11, 2019·Expert Review of Neurotherapeutics·Laura OrsoliniFabrizio Schifano
Dec 17, 2019·Drug Testing and Analysis·Alberto SalomoneMarco Vincenti
Jan 3, 2020·Behavioural Pharmacology·Michael B GatchMichael J Forster
Jul 10, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Joseph J PalamarKatherine M Keyes
Aug 5, 2017·Substance Use & Misuse·Joseph J PalamarCharles M Cleland
Mar 24, 2017·Journal of Analytical Toxicology·Alberto SalomoneMarco Vincenti
Jul 16, 2017·International Journal of Legal Medicine·Bernardino BarcelóFrancesco Paolo Busardò
Aug 20, 2020·The American Journal on Addictions·Joseph J Palamar, Alberto Salomone
May 10, 2017·The American Journal of Drug and Alcohol Abuse·Joseph J PalamarCharles M Cleland
Jun 2, 2017·Human Psychopharmacology·Shanna MarrinanOrnella Corazza
Feb 23, 2019·Journal of Psychoactive Drugs·Ada BeseliaDavid Otiashvili
Feb 7, 2019·Journal of Applied Toxicology : JAT·Rita Roque BravoDiana Dias da Silva
Apr 26, 2018·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Joseph J PalamarScott Sherman
Jun 17, 2020·Journal of Psychopharmacology·Michael B Gatch, Michael J Forster
Dec 6, 2017·Drug Testing and Analysis·K Wing LeungKarl W K Tsim
Oct 31, 2020·Journal of Substance Use·Joseph J PalamarCharles M Cleland
Jan 5, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julie ChasJean-Claude Alvarez
Apr 29, 2021·The International Journal of Neuropsychopharmacology·Alison G P WakefordCarol A Paronis
Jul 13, 2018·ACS Chemical Neuroscience·Lee E DunlapDavid E Olson
Aug 31, 2021·Journal of the American Society for Mass Spectrometry·Henry WestGavin E Reid
Dec 2, 2021·Journal of Analytical Toxicology·Ewelina PieprzycaPiotr Czekaj

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