Detection of bioradicals by in vivo L-band electron spin resonance spectrometry

NMR in Biomedicine
Hirotada Fujii, L J Berliner

Abstract

The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil systems have emerged as the most suitable resonators for in vivo EPR experiments. This paper briefly discusses instrumental aspects as a prelude to several examples related to the in vivo monitoring and detection of bioradicals. Recent progress in detection of bioradicals induced by drugs or chemicals is discussed with regard to nitrosocompounds, nitric oxide and metals in vivo. A clinical EPR application is also discussed.

Citations

Aug 7, 2007·Antioxidants & Redox Signaling·Harold M SwartzValery V Khramtsov
Jun 21, 2006·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Hirotada FujiiMotomichi Sakata
Dec 28, 2007·Free Radical Biology & Medicine·Jeffrey AtkinsonRichard M Epand
Jun 10, 2005·Molecular Nutrition & Food Research·Sascha Rohn, Lothar W Kroh
Dec 13, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nicolas CharlierBernard Gallez
Jul 6, 2014·British Journal of Pharmacology·C CsonkaT Csont
May 18, 2016·British Journal of Pharmacology·Andreas DaiberThomas Münzel
Jun 16, 2009·Free Radical Biology & Medicine·Hao HongWeibo Cai

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