Detection of bladder cancer recurrence by microsatellite analysis of urine

Nature Medicine
G SteinerD Sidransky

Abstract

A reliable, noninvasive method for monitoring patients with transitional cell carcinoma (TCC) of the bladder would be of great clinical benefit. Cystoscopy is currently the "gold standard," but it is invasive, expensive and uncomfortable for the patient. Recently, we demonstrated a novel approach for the detection of primary bladder cancer based on microsatellite analysis of urine DNA. To determine the feasibility of this technique for following-up patients with TCC, we tested serial urine samples from 21 patients who had been treated for bladder cancer with 20 polymorphic microsatellite markers in a blinded fashion. We detected recurrent lesions in 10 out of 11 patients and correctly predicted the existence of a neoplastic cell population in the urine of two patients, 4 and 6 months before cystoscopic evidence of the tumor. The assay was negative in 10 of 10 patients who had no evident cancer. Microsatellite analysis of urine sediment represents a novel and potentially powerful clinical tool for the detection of recurrent bladder cancer.

References

May 20, 1994·Cell·E Ruoslahti, J C Reed
Jan 1, 1994·CA: a Cancer Journal for Clinicians·C C BoringS Montgomery
May 18, 1945·Science·G N Papanicolaou, V F Marshall

❮ Previous
Next ❯

Citations

Jul 3, 1999·Cancer·A Gschwendtner, T Mairinger
Jan 8, 1998·International Journal of Cancer. Journal International Du Cancer·J F LinnD Sidransky
Oct 31, 1998·International Journal of Cancer. Journal International Du Cancer·M ShigyoT Kakizoe
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·M ChristensenT F Orntoft
Apr 10, 1999·Electrophoresis·G SteinerS C Müller
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D SeripaV M Fazio
Sep 19, 2000·Genes, Chromosomes & Cancer·I SardiO Gallo
Oct 3, 2002·Diagnostic Cytopathology·Nara de Matos GranjaCarlos Bedrossian
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Christian HafnerArndt Hartmann
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Najla AmiraHany Soliman
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·R von KnoblochR Hofmann
Oct 9, 2007·Pathology Oncology Research : POR·Péter RieszAndrás Kiss
Aug 4, 2006·Molecular Diagnosis & Therapy·Sudhir Srivastava
Nov 15, 2006·World Journal of Urology·Matthew E NielsenRobert H Getzenberg
Dec 20, 2007·World Journal of Urology·Piyush K AgarwalAshish M Kamat
Sep 3, 2004·Current Treatment Options in Oncology·Gilad E AmielSeth P Lerner
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rebecca Wing-Yan Chan, Cheuk-Chun Szeto
Mar 12, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jin Hwa LeeJung Hyun Chang
May 5, 2005·Urologic Oncology·Brian LittleAiden O'Brien
Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·F KoenigS A Loening
Jun 2, 1998·Lancet·D A Haber, E R Fearon
Jun 21, 2002·European Urology·Carsten GoesslKurt Miller
Apr 24, 1999·Biochimica Et Biophysica Acta·P Cairns, D Sidransky
Feb 4, 1998·Journal of the American College of Surgeons·M M Goldstein, E M Messing
May 7, 2002·Nature Reviews. Cancer·David Sidransky
Jan 1, 1997·Genetic Testing·C L CarterP D Murphy
Dec 2, 1999·Journal of the National Cancer Institute·C F EisenbergerD Sidransky
Jan 4, 2001·Journal of the National Cancer Institute·J ZhangS Cheng
Jul 20, 2006·Journal of the National Cancer Institute·Mohammad Obaidul HoqueDavid Sidransky
Jun 28, 2002·Nucleic Acids Research·Liya GuGuo-Min Li
Oct 3, 1999·Current Opinion in Oncology·D E HensonB S Kramer
Feb 15, 2001·The Journal of Urology·B R Konety, R H Getzenberg
Jan 11, 2001·Advances in Anatomic Pathology·J S Ross, M B Cohen
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paola ParrellaTheresa Nicol

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.