Abstract
Background : Antibiotic resistance among Enterobacteriaceae posts a great challenge to the health care service. The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) is attracting significant attention due to its rapid and global dissemination. The infection is associated with significant morbidity and mortality, thus creating challenges for infection control and managing teams to curb the infection. In Southeast Asia, there have been limited reports and subsequent research regarding CRKP infections. Thus, the study was conducted to characterize CRKP that has been isolated in our setting. Methods : A total of 321 K. pneumoniae were included in the study. Each isolate went through an identification process using an automated identification system. Phenotypic characterization was determined using disk diffusion, modified Hodge test, Epsilometer test, and inhibitor combined disk test. Further detection of carbapenemase genes was carried out using polymerase chain reaction and confirmed by gene sequence analysis. Results : All together, 13 isolates (4.05%) were CRKP and the majority of them were resistant to tested antibiotics except colistin and tigercycline. Among seven different carbapenemase genes studied (blaKPC, ...Continue Reading
References
Jul 21, 2006·Diagnostic Microbiology and Infectious Disease·Soo-Young KimKyungwon Lee
Aug 25, 2007·International Journal of Antimicrobial Agents·Yoav Keynan, Ethan Rubinstein
Aug 23, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T KotlovskyH Sprecher
Apr 24, 2009·Journal of Clinical Microbiology·Fernando PasteranAlejandra Corso
Mar 10, 2010·Antimicrobial Agents and Chemotherapy·Ji-Young RheeKwan Soo Ko
Mar 3, 2011·Mayo Clinic Proceedings·Souha S Kanj, Zeina A Kanafani
Jun 4, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G L Daikos, A Markogiannakis
Jul 5, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D Ben-DavidG Rahav
Aug 16, 2011·Current Opinion in Pharmacology·Rafael Cantón, Patricia Ruiz-Garbajosa
Nov 26, 2011·Journal of Clinical Microbiology·Michelle N D BalmJeanette Teo
Jan 13, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H H BalkhyM Sallah
Feb 1, 2012·Antimicrobial Agents and Chemotherapy·Tsai-Ling LauderdaleShan-Chwen Chang
Dec 25, 2012·Emerging Infectious Diseases·Guillermo V SanchezJose Bordon
Apr 6, 2013·Journal of Medical Microbiology·Jeanette W P TeoRaymond T P Lin
Citations
Jul 6, 2016·Frontiers in Microbiology·Chang-Ro LeeSang Hee Lee
Nov 1, 2016·Clinical Microbiology Reviews·Li-Yang HsuPaul Anantharajah Tambyah
Mar 8, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Golnaz MobasseriKwai Lin Thong
Oct 17, 2017·Journal of the Chinese Medical Association : JCMA·Zahra HosseinzadehMohammad Motamedifar
Oct 30, 2016·Journal of Clinical Laboratory Analysis·Abdullah KilicMehmet Baysallar
Sep 24, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Polly Soo Xi YapCindy Shuan Ju Teh
Jul 3, 2020·Pathogens·András FodorLászló Makrai
May 6, 2016·Antimicrobial Resistance and Infection Control·Nuntra Suwantarat, Karen C Carroll
Dec 16, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Golnaz MobasseriCindy Shuan Ju Teh
Jan 12, 2017·Antimicrobial Resistance and Infection Control·Ye-Mun LowCindy Shuan-Ju Teh
May 6, 2017·Antimicrobial Resistance and Infection Control·Abdul Rahman ZaidahAzian Harun
Apr 7, 2016·Annals of Clinical Microbiology and Antimicrobials·Irmak Baran, Neriman Aksu
Nov 23, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Arnon ChukamnerdSarunyou Chusri
Oct 25, 2017·Indian Journal of Medical Microbiology·Srujana MohantyRajni Gaind
Apr 4, 2021·Pathogens·Min Yi LauCindy Shuan Ju Teh
Sep 28, 2021·Tropical Medicine and Health·Susil PyakurelShiba Kumar Rai
Sep 8, 2021·Journal of Microbiology and Biotechnology·Hanieh TajdozianHo-Yeon Song