Detection of blaIMP4 and blaNDM1 harboring Klebsiella pneumoniae isolates in a university hospital in Malaysia

Emerging Health Threats Journal
Nurul Izzati HamzanZaidah Abdul Rahman

Abstract

Background : Antibiotic resistance among Enterobacteriaceae posts a great challenge to the health care service. The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) is attracting significant attention due to its rapid and global dissemination. The infection is associated with significant morbidity and mortality, thus creating challenges for infection control and managing teams to curb the infection. In Southeast Asia, there have been limited reports and subsequent research regarding CRKP infections. Thus, the study was conducted to characterize CRKP that has been isolated in our setting. Methods : A total of 321 K. pneumoniae were included in the study. Each isolate went through an identification process using an automated identification system. Phenotypic characterization was determined using disk diffusion, modified Hodge test, Epsilometer test, and inhibitor combined disk test. Further detection of carbapenemase genes was carried out using polymerase chain reaction and confirmed by gene sequence analysis. Results : All together, 13 isolates (4.05%) were CRKP and the majority of them were resistant to tested antibiotics except colistin and tigercycline. Among seven different carbapenemase genes studied (blaKPC, ...Continue Reading

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Citations

Nov 1, 2016·Clinical Microbiology Reviews·Li-Yang HsuPaul Anantharajah Tambyah
Mar 8, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Golnaz MobasseriKwai Lin Thong
Oct 17, 2017·Journal of the Chinese Medical Association : JCMA·Zahra HosseinzadehMohammad Motamedifar
Sep 24, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Polly Soo Xi YapCindy Shuan Ju Teh
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Sep 28, 2021·Tropical Medicine and Health·Susil PyakurelShiba Kumar Rai

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Datasets Mentioned

BETA
AJ609296.3

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

GeneDoc
BLAST

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