Detection of breast cancer-related antigens through cDNA phage-displayed protein microarray

Biological Chemistry
Qun BiShenggeng Zhu

Abstract

High-throughput molecular profiling techniques are helpful in the diagnosis of multifactorial disease. In this study, a cDNA-phage-displayed protein microarray using phage particles spotted directly onto it as sensors was used to detect related antigens in breast tumor sera. cDNA sequences from 17 positive clones were determined, which included some sequences encoding known breast cancer-related antigens and proteins related to other diseases, as well as proteins with unknown functions. Our results not only provide some useful information for breast cancer research, but also suggest that the strategy used here would be efficient to search for disease-related proteins and other functional target proteins.

References

Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Olga MinenkovaPaolo Monaci
Sep 15, 2005·Cancer Genetics and Cytogenetics·S PiaskowskiPawel Piotr Liberski
Apr 10, 2007·Biosensors & Bioelectronics·Qun BiShenggeng Zhu
Jul 25, 2007·Human Mutation·Radek CmejlaDagmar Pospisilova
Oct 3, 2007·Cancer Research·Soo-Yeon ParkYoung-Mee Park

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