Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases.

Breast Cancer Research and Treatment
Zhe-Bin LiuJenny C Chang

Abstract

Limited knowledge exists on the detection of breast cancer stem cell (BCSC)-related mutations in circulating free DNA (cfDNA) from patients with advanced cancers. Identification of new cancer biomarkers may allow for earlier detection of disease progression and treatment strategy modifications. We conducted a prospective study to determine the feasibility and prognostic utility of droplet digital polymerase chain reaction (ddPCR)-based BCSC gene mutation analysis of cfDNA in patients with breast cancer. Detection of quantitative BCSC gene mutation in cfDNA by ddPCR mirrors disease progression and thus may represent a valuable and cost-effective measure of tumor burden. We have previously shown that hematological and neurological expressed 1-like (HN1L), ribosomal protein L39 (RPL39), and myeloid leukemia factor 2 (MLF2) are novel targets for BCSC self-renewal, and targeting these genetic alterations could be useful for personalized genomic-based therapy. BCSC mutation detection in cfDNA may have important implications for diagnosis, prognosis, and serial monitoring.

References

Dec 12, 2003·Nature Reviews. Cancer·Matthew Smalley, Alan Ashworth
Nov 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Frank DiehlBert Vogelstein
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hideharu KimuraKazuto Nishio
Aug 26, 2006·Breast Cancer Research and Treatment·Lisa M McShaneUNKNOWN Statistics Subcommittee of NCI-EORTC Working Group on Cancer Diagnostics
May 1, 2008·Journal of the National Cancer Institute·Xiaoxian LiJenny C Chang
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chad J CreightonJenny C Chang
May 13, 2011·Nature Reviews. Cancer·Heidi SchwarzenbachKlaus Pantel
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Mar 15, 2013·The New England Journal of Medicine·Sarah-Jane DawsonNitzan Rosenfeld
Sep 3, 2013·Nature Methods·Christopher M HindsonMuneesh Tewari
May 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Bhuvanesh DaveJenny C Chang
Jun 5, 2015·Methods in Molecular Biology·Ming LuoMax S Wicha
Aug 12, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David ChuBen Ho Park
Aug 28, 2015·Science Translational Medicine·Isaac Garcia-MurillasNicholas C Turner
Jan 4, 2017·Journal of the National Cancer Institute·Bhuvanesh DaveJenny C Chang
Aug 8, 2017·Nature·Dan R RobinsonArul M Chinnaiyan

❮ Previous
Next ❯

Citations

Jan 27, 2021·Toxicon : Official Journal of the International Society on Toxinology·Êndila de Souza BarbosaJacqueline de Almeida Gonçalves Sachett
Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiuling JieYanlin Ma
Mar 25, 2021·Science Signaling·Gihan S GunaratneJonathan S Marchant
May 6, 2021·International Journal of Molecular Sciences·Alessio ArdizzoneIrene Paterniti
Aug 28, 2021·Biomedicines·Irina Palacín-AlianaÁngel Ayuso-Sacido
Nov 14, 2021·Molecular Diagnosis & Therapy·Susana Olmedillas-LópezDamián García-Olmo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Bhuvanesh DaveJenny C Chang
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Julia A BeaverBen Ho Park
Gastrointestinal Cancer Research : GCR
Anastasia Katsiampoura, Scott Kopetz
© 2021 Meta ULC. All rights reserved