Detection of cannabinoids in hair after cosmetic application of hemp oil

Scientific Reports
R PaulC Peake

Abstract

The detection of cannabis constituents and metabolites in hair is an established procedure to provide evidence of exposure to cannabis. We present the first known evidence to suggest that applying hemp oil to hair, as cosmetic treatment, may result in the incorporation of Δ9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD) and in one instance, the metabolite 11-hydroxy-Δ9-tetrahydrocannabinol (THC-OH). 10 volunteers treated their head hair daily with commercially available hemp oil for a period of 6 weeks. Head hair samples were collected before and after the application period. Hair samples were washed with methanol and subjected to clean up via liquid/liquid and solid phase extraction procedures, and then GC-MS/MS for the analysis of THC, CBN, CBD, THC-OH and THC-COOH. Application of hemp oil to hair resulted in the incorporation of one or more cannabis constituents in 89% of volunteers, and 33% of the group tested positive for the three major constituents, THC, CBN and CBD. One volunteer showed low levels of the metabolite THC-OH. We suggest that cosmetic use of hemp oil should be recorded when sampling head hair for analysis, and that the interpretative value of cannabinoid hair measurements from people repor...Continue Reading

References

Mar 10, 1998·Journal of Analytical Toxicology·A Alt, G Reinhardt
Sep 17, 1999·Journal of Analytical Toxicology·V CirimeleB Ludes
Jan 5, 2002·Journal of Analytical Toxicology·G LesonM A ElSohly
Mar 22, 2003·Clinical Pharmacokinetics·Franjo Grotenhermen
Sep 29, 2004·Forensic Science International : Synergy·Michael Uhl, Hans Sachs
Apr 22, 2006·Therapeutic Drug Monitoring·Frank Musshoff, Burkhard Madea
May 20, 2006·Annales pharmaceutiques françaises·J-P Goullé, C Lacroix
Oct 8, 2015·Scientific Reports·Bjoern MoosmannVolker Auwärter
Nov 25, 2016·Forensic Science International : Synergy·Aurélie BerthetChristian Giroud
Mar 18, 2017·The American Journal on Addictions·Joannis N NestorosAristidis M Tsatsakis
Nov 29, 2017·Journal of Pharmaceutical and Biomedical Analysis·Cinzia CittiGiuseppe Cannazza

❮ Previous
Next ❯

Citations

Dec 19, 2020·Clinical, Cosmetic and Investigational Dermatology·Sudhir M BaswanNathan Stern
Apr 30, 2021·Cannabis and Cannabinoid Research·Martin KrsakKristine M Erlandson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.