Detection of cationic surfactants in oral rinses and a disinfectant formulation using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
A P MorrowFolahan O Ayorinde

Abstract

Three commercial oral rinses and one commercial disinfectant formulation were analyzed for the presence of cationic surfactants using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) in the positive ion mode. The product labels on these formulations indicate the presence of cetylpyridinium chloride, tetraalkylammonium or trialkylbenzylammonium chlorides. The resulting MALDI-TOF mass spectra only showed cetylpyridinium, tetraalkylammonium, and trialkylbenzylammonium ions, apparently due to the dissociation of the salts in the ion source. We confirmed the presence of cetylpyridinium salt in the three oral formulations, whereas the disinfectant formulation consisted of a complex mixture of the salts of dioctyldimethylammonium, didecyldimethylammonium, benzylmyristyldimethylammonium, decyloctyldimethylammonium, benzyldecyldimethylammonium, and benzylcetyldimethylammonium. This work demonstrates again the potential for using meso-tetrakis(pentafluorophenyl)porphyrin as a matrix in the MALDI-TOFMS analysis of low molecular weight compounds. This study also demonstrates that the mode of ionization of quaternary ammonium compounds (cationic surfactant salts) under MALDI conditions is by dissoci...Continue Reading

References

Jan 1, 1979·Journal of Pharmaceutical Sciences·J B Lowry
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Oct 1, 1965·Journal of Pharmaceutical Sciences·T F Chin, J L Lach
Aug 19, 1994·Journal of Chromatography. a·J PaesenJ Hoogmartens

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Citations

Mar 22, 2005·Journal of Separation Science·Suhair Yousif Al-JarahAsa Emmer
Jun 1, 2006·Electrophoresis·Bianca Veronica ParaMaria Teresa Galceran
Dec 15, 2004·Journal of Chromatography. a·Oscar NúñezMaria Teresa Galceran
Oct 13, 2001·Journal of Mass Spectrometry : JMS
Jun 9, 2009·Chemical Communications : Chem Comm·Xiaoqiang ChenJuyoung Yoon

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