Abstract
Pericentric inversion of chromosome 16, translocation (16;16) and del(16q), resulting in a chimerical fusion of CBFbeta and MYH11 genes, are typically seen in the M4Eo French-American-British (FAB) classification subset of acute myelogenous leukemia (AML). In this study, we analyzed 70 cases of acute non-lymphoblastic leukemia, mainly of the M4 or M5 type. We report the very unusual presence of the t(16;16) and CBFbeta/MYH11 fusion transcript in an M7 patient. Ten M4Eo and four non-M4Eo patients presented an inv(16), t(16;16) or CBFbeta/MYH11 fusion transcript. In most cases, the common 'A-type' CBFbeta/MYH11 fusion transcript was detected. In addition to the eight different breakpoints and the three alternative splicing variants already described, evidence of a new CBFbeta/MYH11 fusion transcript was found which involves a 785-bp deletion of MYH11. Moreover, two patients had an unusual transcript, to our knowledge only observed once. Only one patient had abnormal eosinophilic differentiation without chromosome 16 cytogenetic abnormalities or detectable CBFbeta/MYH11 fusion. Conversely, only one patient presented CBFbeta/MYH11 fusion without abnormal eosinophilic differentiation. Altogether, our data suggest a correlation betwe...Continue Reading
Citations
Feb 3, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sonya B ShahCarol L Shields
Aug 12, 2009·Journal of Hematopathology·Daniel NeureiterOtto Dietze
Nov 11, 1998·Cancer Genetics and Cytogenetics·M J MozziconacciM Lafage-Pochitaloff
Aug 25, 1999·Cancer Genetics and Cytogenetics·P SharmaA Smith
May 5, 2000·The Biochemical Journal·B D Lichty, S Kamel-Reid
Sep 30, 1999·The New England Journal of Medicine·B LöwenbergA Burnett
Dec 21, 2004·British Journal of Haematology·John T Reilly
Jul 8, 2008·Oncogene·A M S MüllerM Lübbert
Aug 28, 1998·Leukemia & Lymphoma·N AsouK Takatsuki
Dec 7, 2000·Cancer Investigation·G MarcucciC D Bloomfield
Sep 11, 2002·American Journal of Hematology·R BillströmB Johansson
Nov 6, 2007·Cancer Genetics and Cytogenetics·Mar MalloFrancesc Solé
Nov 26, 2009·International Journal of Laboratory Hematology·S GiusianoJ Gabert
Jan 24, 2015·Molecular Cancer·John FischerNicoletta Sacchi
Oct 17, 2003·Leukemia·J GabertJ J M van Dongen
May 10, 2000·Leukemia·S E LangabeerD C Linch
Feb 13, 2002·Leukemia·N GrardelC Preudhomme
Dec 7, 2005·Oncogene·E M RegoP P Pandolfi
Nov 11, 1999·Oncogene·P L DavisJ R Marks
Jun 13, 2000·Oncogene·J X Lin, W J Leonard
Dec 26, 2001·Oncogene·M DavidJ Pierre
Oct 19, 2001·Oncogene·J DuysterS W Morris
May 18, 2000·Oncogene·P RameilJ Imbert
Apr 4, 2017·Pediatric Blood & Cancer·Kim KleinGertjan L Kaspers
Sep 15, 2017·Hematological Oncology·Nathalie Douet-GuilbertMarc De Braekeleer
Sep 20, 2002·Blood·James W VardimanRichard D Brunning