Detection of Cerebrospinal Fluid Leaks: Is There a Radiologic Standard of Care? A Systematic Review

World Neurosurgery
Rachelle EljazzarAlfred M Iloreta

Abstract

Diagnosis of cerebrospinal fluid (CSF) leaks traditionally involves laboratory testing of markers and appropriate imaging. Surgical localization can be difficult, and the inability to accurately localize skull base defects leads to increased rates of repair failure and complications. Many imaging techniques localizing and identifying CSF leaks have been proposed. Comparisons of current and investigational imaging techniques used to localize CSF leaks are reviewed. A comprehensive and systematic search through PubMed, Scopus, and reference lists from relevant articles was completed to identify literature on sensitivities of different imaging methods for localization and detection of CSF leaks. Prospective, retrospective, and case series published since 1995 that addressed imaging techniques for CSF leaks confined to the skull base were included. Sensitivities of each major imaging technique proposed were recorded and analyzed. In total, 133 studies initially were screened from 2125 studies on preliminary search. Of these, 38 studies were included based on inclusion criteria. Studies were segregated by imaging modality. A total of 1000 patients with CSF leaks subsequently were evaluated. Although radionuclide cisternography has b...Continue Reading

Citations

Sep 24, 2019·SLAS Technology·Daniel W BradburyDaniel T Kamei
Aug 29, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Noga LipschitzRavi N Samy
Sep 10, 2020·Surgical Neurology International·Keiichiro OharaYuichi Murayama
Oct 26, 2020·International Forum of Allergy & Rhinology·Christos GeorgalasBradford A Woodworth
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Jun 2, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Jacopo GalliGaetano Paludetti
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Dec 1, 2021·American Journal of Rhinology & Allergy·Michael XieDoron D Sommer

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