Detection of Chlamydiae pneumoniae but not Helicobacter pylori DNA in atherosclerosis plaques

Digestive Diseases and Sciences
Maria P DoreGiuseppe Realdi

Abstract

Chronic infections have been associated with cardiovascular disease. We used bacterial culture, polymerase chain reaction (PCR), and immunohistochemical staining with anti-vacA and anticagA antibodies to search for Helicobacter pylori and Chlamydiae pneumoniae in atherosclerotic plaques obtained at endarterectomy. Serum IgG antibodies to H. pylori and C. pneumoniae were also determined. Thirty-two patients were enrolled. Anti-H. pylori and anti-C. pneumoniae IgG were present in 72% and 81%, respectively. Culture and PCR for H. pylori of vessel walls and plaques were negative. Atherosclerotic plaque and normal vessel sections from H. pylori-negative and- positive patients showed reactivity with anti-vacA and anti-cagA antibodies. C. pneumoniae DNA was amplified in three atherosclerotic lesions. These findings suggest that the association between H. pylori infection and atherosclerosis does not result from continuing direct effects of H. pylori antigens in the vessel walls. Antigens within vessel atherosclerotic plaques cross-react with H. pylori virulence factors and could act as cofactors in determining instability for the atherosclerotic plaques.

Citations

Jan 30, 2016·Journal of Diabetes Research·Alessandro P DelitalaMaria P Dore
Nov 18, 2003·Helicobacter·Hilpi RautelinFrancis Mégraud
May 22, 2004·Alimentary Pharmacology & Therapeutics·A RuzsovicsZ Tulassay
Mar 5, 2005·Digestive Diseases and Sciences·Paolo A TomasiGiuseppe Delitala
Sep 11, 2020·Journal of Atherosclerosis and Thrombosis·Maria Pina DoreGiovanni Mario Pes
Sep 27, 2005·Helicobacter·Maria Pina DoreGiuseppe Realdi
Aug 26, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Eugenia AriasGustavo Sevlever
Jul 19, 2013·European Heart Journal·Gerhard Rogler, Giuseppe Rosano
Dec 14, 2018·Experimental Biology and Medicine·Maria Pina DoreGiuseppe Realdi
Sep 7, 2004·Helicobacter·Antonio GasbarriniStephanie A Chisholm
Mar 10, 2016·International Journal of Environmental Research and Public Health·Dandan SunYuan Yuan
Mar 15, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Islam KaklikkayaFahri Ozcan

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