PMID: 7089037May 1, 1982Paper

Detection of cholinergic mediation of behavior in 7-, 9-, and 12-day old rat pups

Pharmacology, Biochemistry, and Behavior
G J SmithN E Spear


A training procedure that permitted infant rats (7, 9, and 12 days old) to acquire a T maze discrimination to escape footshock (Experimental 1) was used to study the effects of the cholinergic antagonist, scopolamine hydrobromide (0, 0.2 mg/kg and 0.8 mg/kg) (Experiment 2). These results indicated that (1) Scopolamine had no effect on T maze choice behavior, unlike previous results for 15- and 23-day old rats, but (2) scopolamine did increase latency to choice in the discrimination task at all ages, an effect previously seen in 15-day old animals, but opposite that seen after scopolamine administration to 23-day old animals or adults. This "paradoxical" effect of scopolamine on response latency is present approximately two weeks prior to earlier estimates of the time course of maturation of the cholinergic system.


Nov 1, 1979·Experimental Neurology·M O Leblanc, B H Bland
Aug 1, 1979·Journal of Comparative and Physiological Psychology·G J SmithN E Spear
Mar 1, 1976·European Journal of Pharmacology·L A BaezR Schein
Oct 1, 1976·Pharmacology, Biochemistry, and Behavior·J M Murphy, Z M Nagy
Sep 1, 1970·Journal of Comparative and Physiological Psychology·H C FibigerB A Campbell


Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·G Calamandrei, A Valanzano
Aug 19, 1991·Brain Research. Developmental Brain Research·G CalamandreiE Alleva
Jan 23, 1995·Behavioural Brain Research·G Calamandrei, E Alleva
Jan 1, 1996·Brain Research Bulletin·L RicceriG Calamandrei
Sep 1, 1990·Neurotoxicology and Teratology·L P Spear
May 20, 1998·Pharmacology, Biochemistry, and Behavior·D H OverstreetD S Janowsky
Apr 16, 2004·Behavioural Brain Research·Igor BranchiE Alleva
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·C W HennigJ L Allen
Mar 1, 1990·Developmental Psychobiology·J Myslivecek, J Hassmannová
Feb 25, 2000·Neurobiology of Learning and Memory·C BrandnerF Schenk

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