Abstract
To assess whether pre-high-dose therapy (HDT)-related factors play a critical role in the development of therapy-related myelodysplasia (tMDS) or secondary acute myelogenous leukemia (sAML). Twenty-nine of 230 patients with a primary diagnosis of non-Hodgkin's lymphoma (NHL) developed tMDS/sAML after HDT comprising cyclophosphamide and total-body irradiation (TBI) supported by autologous hematopoietic progenitor cells. G-banding and fluorescence in-situ hybridization (FISH) were used to detect clonal cytogenetic abnormalities. The majority of patients showed complex karyotypes at diagnosis of tMDS/sAML containing, in particular, complete or partial loss of chromosomes 5 and/or 7. Using single locus-specific FISH probes, significant levels of clonally abnormal cells were found before HDT in 20 of 20 tMDS/sAML patients screened, compared with three of 24 patients screened who currently have not developed tMDS/sAML, at a median follow-up of 5.9 years after HDT. Prior cytotoxic therapy may play an important etiologic role and may predispose to the development of tMDS/sAML. Using a triple FISH assay designed to detect loss of chromosomal material from 5q31, 7q22, or 13q14, significant levels of abnormal cells can be detected before ...Continue Reading
References
Jan 4, 1990·The New England Journal of Medicine·J M KaldorD Assouline
Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J GallagherT A Lister
Dec 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KantarjianE J Freireich
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W JohnsonT A Lister
Dec 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L DarringtonS R Tarantolo
Dec 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M StoneA S Freedman
Jun 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A Z RohatinerJ Matthews
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P MarolleauC Gisselbrecht
Nov 1, 1996·British Journal of Haematology·R GovindarajanG Tricot
Oct 27, 1997·Leukemia·P R TaylorS J Proctor
Oct 27, 1997·Leukemia·J Pedersen-BjergaardC Geisler
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Pedersen-BjergaardB Johansson
Sep 28, 1998·Biochimica Et Biophysica Acta·C A Felix
Oct 28, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M ForanA Z Rohatiner
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J W FriedbergA S Freedman
Oct 3, 1999·British Journal of Cancer·C N HarrisonD C Linch
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J ApostolidisA Z Rohatiner
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I N MicallefA Z Rohatiner
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I Yakoub-AghaE Gluckman
Citations
Jun 13, 2002·Reviews in Clinical and Experimental Hematology·Theo de WitteAnton Schattenberg
Dec 5, 2006·Bone Marrow Transplantation·C R HakeT S Fenske
Jul 1, 2008·The Oncologist·Marshall A Lichtman
Jul 16, 2008·Bone Marrow Transplantation·L J CostaM R Litzow
Dec 4, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim M IllidgeFranck Morschhauser
Jan 2, 2016·Oncology Letters·Dan YangMingzhi Zhang
Feb 10, 2018·Current Treatment Options in Oncology·Ivetta Danylesko, Avichai Shimoni
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heinz SillMichael G Schimek
Mar 8, 2003·Blood·Sonali M SmithRichard A Larson
Jan 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher J GibsonBenjamin L Ebert
Oct 21, 2003·Leukemia & Lymphoma·Martin MohrenKathleen Jentsch-Ullrich
Aug 30, 2002·Leukemia·G NicholsC Hesdorffer
Sep 27, 2007·Blood·Bart BarlogieJeffrey Sawyer
Oct 30, 2012·Leukemia & Lymphoma·Yuanlin XuPing Wang
Sep 13, 2013·Cancer Biology & Therapy·Mojtaba AkhtariJames O Armitage
Sep 14, 2016·World Journal of Stem Cells·Mohammad Faizan ZahidShahrukh K Hashmi
May 1, 2004·Blood·Donald W MilliganUNKNOWN National Cancer Research Institute Haematological Studies Group
Oct 20, 2004·British Journal of Haematology·Cynthia L TozeDonna E Hogge
Apr 25, 2007·Blood·Richard A NashDaniel E Furst
Oct 19, 2004·Bone Marrow Transplantation·W W TseK Van Besien
Jul 15, 2003·Bone Marrow Transplantation·R HoweM R Litzow
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ravi BhatiaSmita Bhatia
Nov 15, 2002·International Journal of Hematology·Gordon W Dewald
Sep 25, 2002·Cancer Detection and Prevention·Marilyn L SlovakJoyce L Murata-Collins
Mar 4, 2006·Blood Reviews·Koen Van Besien