Detection of chromosome abnormalities pre-high-dose treatment in patients developing therapy-related myelodysplasia and secondary acute myelogenous leukemia after treatment for non-Hodgkin's lymphoma

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
D M LillingtonA Z Rohatiner

Abstract

To assess whether pre-high-dose therapy (HDT)-related factors play a critical role in the development of therapy-related myelodysplasia (tMDS) or secondary acute myelogenous leukemia (sAML). Twenty-nine of 230 patients with a primary diagnosis of non-Hodgkin's lymphoma (NHL) developed tMDS/sAML after HDT comprising cyclophosphamide and total-body irradiation (TBI) supported by autologous hematopoietic progenitor cells. G-banding and fluorescence in-situ hybridization (FISH) were used to detect clonal cytogenetic abnormalities. The majority of patients showed complex karyotypes at diagnosis of tMDS/sAML containing, in particular, complete or partial loss of chromosomes 5 and/or 7. Using single locus-specific FISH probes, significant levels of clonally abnormal cells were found before HDT in 20 of 20 tMDS/sAML patients screened, compared with three of 24 patients screened who currently have not developed tMDS/sAML, at a median follow-up of 5.9 years after HDT. Prior cytotoxic therapy may play an important etiologic role and may predispose to the development of tMDS/sAML. Using a triple FISH assay designed to detect loss of chromosomal material from 5q31, 7q22, or 13q14, significant levels of abnormal cells can be detected before ...Continue Reading

References

Jan 4, 1990·The New England Journal of Medicine·J M KaldorD Assouline
Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J GallagherT A Lister
Dec 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KantarjianE J Freireich
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W JohnsonT A Lister
Dec 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M StoneA S Freedman
Jun 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A Z RohatinerJ Matthews
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P MarolleauC Gisselbrecht
Nov 1, 1996·British Journal of Haematology·R GovindarajanG Tricot
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Pedersen-BjergaardB Johansson
Sep 28, 1998·Biochimica Et Biophysica Acta·C A Felix
Oct 28, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M ForanA Z Rohatiner
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J W FriedbergA S Freedman
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J ApostolidisA Z Rohatiner
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I N MicallefA Z Rohatiner

❮ Previous
Next ❯

Citations

Jun 13, 2002·Reviews in Clinical and Experimental Hematology·Theo de WitteAnton Schattenberg
Dec 4, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim M IllidgeFranck Morschhauser
Feb 10, 2018·Current Treatment Options in Oncology·Ivetta Danylesko, Avichai Shimoni
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heinz SillMichael G Schimek
Jan 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher J GibsonBenjamin L Ebert
Oct 21, 2003·Leukemia & Lymphoma·Martin MohrenKathleen Jentsch-Ullrich
Sep 14, 2016·World Journal of Stem Cells·Mohammad Faizan ZahidShahrukh K Hashmi
Oct 19, 2004·Bone Marrow Transplantation·W W TseK Van Besien
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ravi BhatiaSmita Bhatia
Sep 25, 2002·Cancer Detection and Prevention·Marilyn L SlovakJoyce L Murata-Collins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.