Detection of ciguatoxin-like and paralysing toxins in Trichodesmium spp. from New Caledonia lagoon

Marine Pollution Bulletin
Anne-Sophie KerbratDominique Laurent

Abstract

Marine pelagic cyanobacteria Trichodesmium are widespread in the New Caledonia lagoon. Blooms of these Oscillatoriales are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain certain types of paralysing toxins. In the present study, toxicity experiments were conducted on lipid- and water-soluble extracts of freeze-dried samples of these cyanobacteria. Lipid-soluble fractions revealed a ciguatoxin-like activity in both in vivo (mouse bioassay) and in vitro (mouse neuroblastoma cells assay and receptor binding assay using tritiated brevetoxin-3) assays. The water-soluble fractions tested on mice exhibited neurotoxicity with paralytic symptoms. These toxicities have also been observed with benthic filamentous cyanobacteria within the Oscillatoriales order, also collected in New Caledonia. This study provides an unprecedented evidence of the toxicity of Trichodesmium species from the New Caledonia lagoon. This survey also demonstrates the possible role of these cyanobacteria in ciguatera fish poisoning.

References

Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·S P HawserE J Carpenter
Jan 27, 1999·Toxicon : Official Journal of the International Society on Toxinology·M Y DechraouiA M Legrand
Nov 15, 2000·International Journal of Food Microbiology·L Lehane, R J Lewis
Mar 2, 2005·Toxicology and Applied Pharmacology·C Wiegand, S Pflugmacher
Dec 30, 2006·Molecular Nutrition & Food Research·Marian E van ApeldoornGuido J I Bakker
Jul 17, 2007·Toxicon : Official Journal of the International Society on Toxinology·H T DariusM Chinain
Nov 14, 2008·Marine Drugs·Melissa A FriedmanAndrew Reich

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Citations

Jan 5, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ralph PawlowiezMireille Chinain
Mar 10, 2016·Chemical Research in Toxicology·Luis M Botana
Sep 29, 2011·Toxicon : Official Journal of the International Society on Toxinology·Eric CluaClaude Chauvet
Oct 30, 2016·Toxicon : Official Journal of the International Society on Toxinology·Abdulrahman Al MuftahMete Yilmaz
Nov 26, 2019·Interdisciplinary Toxicology·Enver Ersoy AndedenBelma Aslim

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