Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
Roxy SeniorRAMP-1 and RAMP-2 Investigators

Abstract

To determine if perfusion stress echocardiography (PSE) with Imagify (perflubutane polymer microspheres) is comparable to stress perfusion imaging using (99m)Tc single photon emission computed tomography (SPECT) for coronary artery disease (CAD) detection. PSE is a novel technique for evaluating myocardial perfusion. RAMP (real-time assessment of myocardial perfusion)-1 and -2 were international, Phase 3 trials that evaluated the ability of PSE with Imagify, to detect CAD. Chronic, stable, chest pain patients (n=662) underwent Imagify PSE and gated SPECT imaging at rest and during dipyridamole stress. Independent blinded cardiologists [three PSE readers per trial, and four SPECT readers (one for RAMP-1, three for RAMP-2)] interpreted images. CAD was defined by quantitative coronary angiography or 90-day outcome with clinical review. Accuracy, sensitivity, and specificity were evaluated using non-inferiority analysis (one-sided alpha=0.025) compared with SPECT. SPECT results for RAMP-1 and -2 were: accuracy (70%, 67%), sensitivity (78%, 61%), and specificity (64%, 76%). Accuracy of all six PSE readers was non-inferior to SPECT (66-71%, P<or=0.004). Four demonstrated non-inferior sensitivity (68-77%, P<or=0.002), three demonstrat...Continue Reading

References

May 18, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Y H LiuF J Wackers
May 5, 2001·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A J RainbirdP A Pellikka
Sep 8, 2001·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·B KuerstenM Vannan
Mar 1, 2002·Statistics in Medicine·Jun-mo Nam, William C Blackwelder
Jul 3, 2002·Circulation·Jian-Ping BinSanjiv Kaul
Feb 23, 2005·Expert Review of Cardiovascular Therapy·Hiroshi Ito
Mar 1, 2005·Journal of the American College of Cardiology·Rolf VogelChristian Seiler
Aug 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julie A StraubHoward Bernstein
Nov 9, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Stuart MoirThomas H Marwick
Apr 4, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Siri MalmTerje Skjarpe
May 15, 2007·Journal of the American College of Cardiology·Cheuk-Man YuJae K Oh
Dec 25, 2007·Journal of the American College of Cardiology·Michael L MainPaul A Grayburn
Apr 10, 2009·JACC. Cardiovascular Imaging·James E Udelson

❮ Previous
Next ❯

Citations

May 18, 2011·Journal of Applied Physics·Parag V ChitnisJeffrey A Ketterling
Dec 22, 2015·Expert Review of Cardiovascular Therapy·Anastasia VamvakidouRoxy Senior
Jan 10, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Damianos ChristofidesMichalakis Averkiou
Oct 10, 2015·IEEE Transactions on Medical Imaging·Damianos ChristofidesMichalakis Averkiou
Aug 13, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sanjiv Kaul, Kevin Wei
Sep 8, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Brijesh AnantharamRoxy Senior
Dec 21, 2017·Journal of Drug Targeting·Shiying WangAlexander L Klibanov
Sep 28, 2017·European Heart Journal Cardiovascular Imaging·Roxy SeniorUNKNOWN EACVI Scientific Documents Committee for 2014–16 and 2016–18
Sep 29, 2011·Circulation. Cardiovascular Imaging·Thomas R PorterSharon L Mulvagh
Apr 22, 2009·Current Cardiology Reports·Rajesh K Chelliah, Roxy Senior
Jul 20, 2010·European Journal of Nuclear Medicine and Molecular Imaging·David Cosgrove, Nathalie Lassau
Sep 25, 2010·Nature Communications·Warren R J D GallowayDavid R Spring
Aug 6, 2013·Journal of Cardiovascular Translational Research·Alexander L Klibanov
Dec 12, 2012·Journal of Cardiovascular Medicine·Gaetano A LanzaUNKNOWN Gruppo di Studio di Fisiopatologia Coronarica e Microcircolazione, Società Italiana di Cardiologia
Aug 3, 2013·European Heart Journal Cardiovascular Imaging·Sanjeev BhattacharyyaUNKNOWN British Society of Echocardiography
Feb 13, 2014·European Heart Journal Cardiovascular Imaging·Sanjeev Bhattacharyya, Roxy Senior
Oct 9, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Diwakar Jain, Zuo-Xiang He
Feb 11, 2015·Current Cardiology Reports·Thomas R Porter, Feng Xie
Mar 10, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Roxy SeniorPetros Nihoyannopoulos
Jul 25, 2012·AJR. American Journal of Roentgenology·Sunil Unnikrishnan, Alexander L Klibanov
Jun 4, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James E Udelson
Nov 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·E AlvarezJ Rychak
Dec 24, 2011·European Heart Journal Cardiovascular Imaging·Benoy Nalin Shah, Roxy Senior
Nov 13, 2020·Investigative Radiology·Alexander L Klibanov
Jun 8, 2021·European Heart Journal Cardiovascular Imaging·Ana G AlmeidaUNKNOWN 2018–2020 EACVI President:
Mar 27, 2010·Revista española de cardiología·Río Aguilar-TorresRicardo Vivancos-Delgado

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.