PMID: 9179756Jun 1, 1997Paper

Detection of coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

Journal of Medical Virology
L AndréolettiP Wattré

Abstract

Enteroviruses may be linked to insulin-dependent diabetes mellitus (IDDM). The prevalence of enteroviral (EV) infection at onset of adult IDDM was investigated by detection of specific EV sequences in peripheral blood using a reverse transcription and a seminested polymerase chain reaction (seminested RT-PCR). EDTA-treated whole blood samples taken from 12 newly diagnosed IDDM patients with ketosis or ketoacidosis were examined. The comparison groups were 12 adult patients suffering from metabolic decompensation in the course of IDDM, 12 adult patients with decompensated non-IDDM, and 15 healthy adults without any presumed EV infection or metabolic disease. EV genome was detected in five of 12 (42%) newly diagnosed IDDM patients and in one of 12 (8%) patients in the course of IDDM. By contrast, none of the 12 non-IDDM patients and none of the 15 healthy adults had EV sequences in whole blood. Subsequent sequencing of the EV PCR products from the six positive patients showed a significant homology with Coxsackie B3 or B4 viruses, and some common patterns were observed among the sequences. The present study demonstrates that Coxsackie B virus RNA sequences can be detected in peripheral blood from patients at the onset or in the c...Continue Reading

References

May 24, 1979·The New England Journal of Medicine·J W YoonA L Notkins
Nov 1, 1992·Biochemical Society Transactions·T M SzopaK W Taylor
Apr 1, 1991·Clinical Microbiology Reviews·H A Rotbart
Oct 1, 1991·Annals of Medicine·J W Yoon
May 18, 1989·Nature·S Kwok, R Higuchi
Feb 1, 1981·Diabetologia·A H BarnettD A Pyke
Nov 1, 1995·Journal of Virology·A I Ramsingh, D N Collins
Jul 22, 1995·Lancet·G B ClementsK W Taylor

❮ Previous
Next ❯

Citations

Jan 10, 2002·The Journal of Clinical Investigation·Marc S HorwitzNora Sarvetnick
Apr 16, 2005·Molecular and Cellular Biology·Nicole LiadisMinna Woo
Mar 16, 2011·The Journal of Clinical Investigation·Stephen A McCartneyMarco Colonna
Apr 29, 2011·Journal of Virology·Outi PaloheimoMaija Vihinen-Ranta
Aug 18, 1999·Immunological Reviews·M S Horwitz, N Sarvetnick
May 20, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Susanne M CabreraMartin J Hessner
May 25, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·J GreenR Newton
Dec 18, 2003·Annals of the New York Academy of Sciences·Sisko TauriainenHeikki Hyöty
Dec 18, 2003·Annals of the New York Academy of Sciences·M Steven Oberste, Mark A Pallansch
Apr 18, 2003·Clinical and Experimental Immunology·K SadeharjuUNKNOWN Finnish TRIGR Study Group
Jan 6, 2009·Annals of the New York Academy of Sciences·Rita BortellAldo A Rossini
Dec 25, 2008·Journal of Medical Virology·Haider Al-HelloMerja Roivainen
Feb 15, 2007·Cellular Microbiology·Matthijs KramerFrank J M van Kuppeveld
Oct 21, 2011·Pediatric Diabetes·Oscar Diaz-HortaAntonio Toniolo
Apr 14, 2012·Journal of Medical Virology·Marja-Leena Simonen-TikkaMerja Roivainen
Mar 23, 2013·Pediatric Diabetes·Maria E CraigWilliam D Rawlinson
Jan 6, 2010·Reviews in Medical Virology·S TracyK Kono
Jun 26, 2015·European Journal of Clinical Investigation·Enagnon Kazali AlidjinouDidier Hober
Oct 18, 2005·The International Journal of Biochemistry & Cell Biology·Merja Roivainen
Jun 21, 2005·Cellular Immunology·Christophe Filippi, Matthias von Herrath
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Heikki Hyöty
Aug 19, 2015·Current Diabetes Reports·Antje PetzoldKlaus-Peter Knoch
Aug 12, 2014·Journal of Medical Virology·Steven TracyNora Chapman
Sep 22, 2012·Islets·Nora M ChapmanSteven Tracy
Oct 31, 2008·Diabetes·Christophe M Filippi, Matthias G von Herrath
Jun 9, 2016·Scientifica·Hifsa MobeenMuhammad Kashif
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·C NairnG B Clements
Dec 4, 2003·Diabetes/metabolism Research and Reviews·Ruben Varela-Calvino, Mark Peakman
Jul 13, 2002·American Journal of Medical Genetics·Hans K AkerblomMikael Knip
Jan 25, 2011·Cellular & Molecular Immunology·Urs Christen, Matthias G von Herrath

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.