PMID: 11322122Apr 27, 2001Paper

Detection of craniospinal dissemination of intracranial germ cell tumours based on serum and cerebrospinal fluid levels of tumour markers

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
T NishizakiM Suzuki

Abstract

Nineteen intracranial germ cell tumours treated during the past 11 years were evaluated retrospectively. The tumours were classified into three groups according to the level of alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) in serum and cerebrospinal fluid, and the optimal treatment for each group was determined. Group A consisted of patients with normal titres of AFP and HCG, group B of patients with relatively high titres (< 10 times normal), and group C comprised patients with higher titres ( 10 times normal levels). In group A, an appropriate field and dose of irradiation was necessary to prevent craniospinal dissemination. In group B, none of four patients who underwent total or subtotal resection of the tumour had craniospinal disseminatio n or tumour recurrence, whereas dissemination occurred in four further patients, including two who had received radiochemotherapy only, and two who had undergone partial resection of the tumour. While patients in group C had dissemination at the time of initial diagnosis, most patients in group B developed dissemination more than 10 months after initial treatment, suggesting that the type of treatment received as first line therapy is important in patients in this g...Continue Reading

Citations

Oct 21, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Lester LeeTibor Hortobágyi
Jan 1, 2009·Pituitary·Luiz Eduardo Armondi WildembergMônica Roberto Gadelha
Oct 2, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Qiang ShiXusheng Huang
Apr 29, 2014·Journal of Neuro-oncology·Nardin SamuelDavid Malkin
Jul 10, 2010·AJNR. American Journal of Neuroradiology·X-F LvJ Zhang
Oct 9, 2019·Neuro-oncology·Austin K MattoxChetan Bettegowda
Aug 9, 2020·Journal of Neuropathology and Experimental Neurology·Karen TangMatija Snuderl
Apr 23, 2004·Current Neurology and Neuroscience Reports·Casilda Balmaceda, Jonathan Finlay
May 1, 2021·International Journal of Molecular Sciences·Severa BundaGelareh Zadeh

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