PMID: 9184638Jun 1, 1997Paper

Detection of CSF-specific oligoclonal antibodies to recombinant JC virus VP1 in patients with progressive multifocal leukoencephalopathy

Journal of Neuroimmunology
C J SindicT Weber

Abstract

The intrathecal synthesis of antibodies against recombinant VP1, the major structural protein of JC virus (JCV), was studied in 18 patients with progressive multifocal leukoencephalopathy (PML) and in 31 patients with various neurological disorders. Two methods were used, the calculation of an antibody specific index (ASI) on one hand and an antigen-driven immunoblotting for the detection of oligoclonal antibodies on the other. Most PML patients displayed an elevated (> 1.5) ASI (78%) and anti-VP1 oligoclonal antibodies restricted to the cerebrospinal fluid (55%). Only two other patients (one case each of multiple sclerosis and of neuroborreliosis) also showed an intrathecal synthesis of anti-VP1 oligoclonal antibodies, likely as a result of a 'polyspecific' reaction within the central nervous system.

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Citations

Jun 18, 2003·Journal of the Neurological Sciences·Alison J E GreenLev G Goldfarb
May 16, 2000·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B GuillaumeT Weber
Dec 15, 2010·Journal of Skin Cancer·Venura SamarasingheJohn T Lear
Jul 21, 2011·Journal of Skin Cancer·Vanessa Smith, Shernaz Walton
Dec 6, 2012·Journal of Skin Cancer·Justin LeeElizabeth Barnes
Dec 2, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Gregory P OwensJeffrey L Bennett
May 12, 2006·Neurological Research·Gregory P OwensMark P Burgoon
Jul 29, 2008·Neurologic Clinics·Thomas Weber
Mar 6, 2015·Journal of Neurovirology·Ivan JelcicRoland Martin
Jun 21, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hans H HirschCeline Leboeuf
Jun 5, 2015·Frontiers in Immunology·Deniz DuraliYassine Taoufik
Jan 5, 2000·Multiple Sclerosis : Clinical and Laboratory Research·D KarussisO Abramsky
May 19, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Daniele FocosiMario Petrini
Dec 7, 2010·Nature Reviews. Neurology·Bruce J BrewAvindra Nath
Jul 17, 1999·Medizinische Klinik·J C WasmuthJ K Rockstroh
Mar 5, 2020·Journal of Medical Case Reports·James Forryan, Jun Yong

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