PMID: 9532236Apr 9, 1998Paper

Detection of cytotoxic activity on Vero cells in clinical isolates of Serratia marcescens

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
G V CarbonellR M Yanaguita

Abstract

Cytotoxin production was studied in 60 Serratia marcescens strains isolated from hospitalized patients. Association of cytotoxic activity with serotype, source of isolation and presence of plasmids was also evaluated. Thirteen of the 60 S. marcescens strains produced a cytotoxic effect on Vero cells. These strains were isolated from distinct clinical sources and classified into seven different serotypes (O1:H7; O4:NM; O10:NT; O19:NM; O6,14:H4; O6,14:NM and O6,14:H1). No relationship was observed between cytotoxic activity and clinical source or serotypes of the strains. Plasmids from five cytotoxin-producing S. marcescens strains were transferred to E. coli K12/711. The transconjugants did not exhibit cytotoxicity, indicating that the cytotoxic effect is not plasmid-mediated among these strains. Although a cytotoxic activity was demonstrated in filtrates of some S. marcescens strains, further studies should be performed to assess the role of this toxin in pathogenesis.

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Citations

Dec 20, 2011·Current Microbiology·K A BettelheimP N Goldwater
Feb 5, 2004·Research in Microbiology·Gleize Villela CarbonellTomomasa Yano
May 9, 2000·FEMS Immunology and Medical Microbiology·G V CarbonellB A Fonseca
Feb 21, 2002·Infection and Immunity·Kent B MartySteven R Blanke
Jul 28, 2012·Journal of Clinical Microbiology·Tayyab RehmanLeonardo Seoane
Jan 19, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hideharu HagiyaKazunori Tomono
Mar 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G V CarbonellT Yano
May 16, 2006·Acta Microbiologica Et Immunologica Hungarica·Ana P RodriguesH D M Coutinho

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