Detection of decay-accelerating factor in stool specimens of patients with colorectal cancer

Gastroenterology
Motowo MizunoTakao Tsuji

Abstract

Colorectal cancers have an increased expression of decay-accelerating factor (DAF). The aim of this study was to determine whether stool specimens of patients with colorectal cancer contain increased amounts of DAF. DAF was measured using an immunoassay in the stool specimens of 40 persons with colorectal cancer, 18 with colorectal adenomatous polyps, 13 with upper gastrointestinal cancer, and 41 without gastrointestinal disease. Stool DAF concentrations in patients with colorectal cancer (0-9.8 ng/g stool; median, 1.6 ng/g) were significantly higher than those in patients with adenoma (0-6.4 ng/g; median, 0 ng/g) (P < 0.05), patients with upper gastrointestinal cancer (0-3.1 ng/g; median, 0 ng/g) (P < 0.05), and subjects without gastrointestinal disease (0-3.4 ng/g; median, 0 ng/g) (P < 0.01). Resection of colorectal cancers caused a marked decrease in stool DAF concentrations. The stool DAF test was positive in a substantial portion of patients with colorectal cancer whose tumors were small ( < 2 cm), at an early TNM stage, or unassociated with fecal occult blood positivity. The sensitivity of the test for colorectal cancer was 55%, and the specificity was 85%. The measurement of stood DAF deserves evaluation as a test for de...Continue Reading

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Citations

Nov 23, 2000·Journal of Surgical Oncology·S Ottó, S Eckhardt
Oct 1, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Martin KolevRossen Donev
Apr 22, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A SchmittW G Dippold
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Jun 3, 2016·Clinical and Translational Gastroenterology·Tobias NiedermaierHermann Brenner
Nov 26, 2003·The American Journal of Gastroenterology·Masakatsu MizunoYasushi Shiratori
Jun 21, 2006·Biochimica Et Biophysica Acta·Jan-Henrik MikeschBurkhard Brandt
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitsunori HiguchiMitsukazu Gotoh

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