Detection of degradation products of chemical warfare agents by highly porous molecularly imprinted microspheres

The Analyst
Lucie MalosseAlain Siove

Abstract

The multiplication of terrorist actions in the recent events is alarming and the detection of chemical warfare agents (CWAs) has become one of the highest research priorities in the fields of security and public health. The biomimetic properties of molecularly imprinted polymers (MIPs) render them attractive for molecular recognition as well as sensing purposes. The degradation products of easily hydrolysable organophosphorus nerve agents such as pinacolyl methylphosphonate (PMP), a hydrolysis by-product of soman, are often used as templates in MIP synthesis. In this study, we describe the first example of PMP-imprinted polymer microspheres synthesized by precipitation polymerization. This one-step process involves methacrylic acid (MAA) as the monomer and divinylbenzene (DVB) as the cross-linker, in a toluene/acetonitrile mixture. Subsequent morphological characterizations of the PMP-imprinted particles show that they have diameters between 1 and 10 mum (as opposed to 4-5 mum for the non-imprinted microspheres), surface areas of up to 680 m(2) g(-1) and high porosities with pore sizes smaller than 2 nm. The present investigation also evidences the imprinting effect via batch binding experiments and reports on the use of a nove...Continue Reading

References

Dec 26, 2001·Chemical Reviews·K Haupt, K Mosbach
Apr 2, 2002·Analytical Chemistry·Iva ChianellaAnthony P F Turner

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Citations

Jun 15, 2011·Chemical Reviews·Kibong KimDavid G Churchill
Dec 15, 2015·Chemical Reviews·Yoon Jeong JangDavid G Churchill
Nov 21, 2009·Journal of Chromatography. a·Gloria Uccello-BarrettaFederica Balzano
Jul 25, 2009·Chemistry : a European Journal·Yi Ge, Anthony P F Turner
Apr 5, 2014·Journal of Molecular Recognition : JMR·Michael J WhitcombeIan A Nicholls

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