Detection of dengue NS1 and NS3 proteins in placenta and umbilical cord in fetal and maternal death

Journal of Medical Virology
Priscila Conrado Guerra NunesFlávia Barreto dos Santos

Abstract

In Brazil, dengue is a public health problem with the occurrence of explosive epidemics. This study reports maternal and fetal deaths due to dengue and which tissues of placenta and umbilical cord were analyzed by molecular methods and immunohistochemistry. The dengue NS3 and NS1 detection revealed the viral presence in different cells from placenta and umbilical cord. In the latter, DENV-2 was detected at a viral titer of 1,02 × 10(4) amounts of viral RNA. It was shown that the DENV markers analyzed here may be an alternative approach for dengue fatal cases investigation, especially involving maternal and fetal death. J. Med. Virol. 88:1448-1452, 2016. © 2016 Wiley Periodicals, Inc.

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Citations

Jan 16, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Christiane Fernandes RibeiroRita Maria Ribeiro Nogueira
Sep 15, 2017·Pathogens and Disease·Moises León-JuárezEnrique Reyes-Muñoz
Jun 3, 2020·Systems Biology in Reproductive Medicine·Isabela Moreti RibeiroFernanda R Giachini
Apr 4, 2021·Viruses·Natália SalomãoPatrícia Brasil

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