Detection of desmethyldiazepam and diazepam in brain of different species and plants

Biochemical Pharmacology
E UnseldU Klotz

Abstract

Recent data suggest that desmethyldiazepam (DD), a major metabolite of several benzodiazepines (BZD), might be of natural origin. Therefore we tried to quantify DD and diazepam (D) in animals during maturation (e.g. hen, chicken, eggs), in brain of species at different evolutionary stages e.g. salmon, frog, monitor/reptile, rat, cat, dog, deer, bovine) including newborn and adult humans. Since low concentrations of DD (range 0.01-0.04 ng/g wet wt) and D (range 0.005-0.02 ng/g) could be measured in different species by sensitive and specific mass spectrometry (GC-MS), we analysed also several plants (e.g. maize corn, lentils, potatoes, soybeans, rice, mushrooms). Again, DD and D could be detected in low amounts (0.005-0.05 ng/g) in some plant products. This would suggest that DD and D might be of natural origin and incorporated via the foodchain into the animal and human body. The biological role or clinical relevance of these intriguing findings need still to be elucidated.

References

Apr 21, 1977·Nature·R F Squires, C Brastrup
Feb 1, 1975·The Journal of Clinical Investigation·U KlotzG R Wilkinson
Nov 1, 1988·Trends in Neurosciences·E UnseldU Klotz
Jan 1, 1987·Journal of Neural Transmission·J WildmannR Maurer
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L SangameswaranA L De Blas
Dec 20, 1965·Journal of the American Chemical Society·W LeimgruberF Schenker

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Citations

Jan 1, 1992·Molecular Neurobiology·J H MedinaA C Paladini
Jan 1, 1990·Biochemical Pharmacology·E UnseldU Klotz
Apr 14, 1990·Lancet·U Klotz
Dec 20, 1993·Behavioural Brain Research·J H MedinaI Izquierdo
Oct 31, 1991·Biochemical and Biophysical Research Communications·M A PivaC Peña
Feb 7, 2001·Biochemical Pharmacology·R AvalloneM Baraldi
Mar 29, 1991·Biochemical and Biophysical Research Communications·C PeñaA C Paladini
Oct 20, 2005·Sleep Medicine Reviews·Pietro CortelliPasquale Montagna
Nov 14, 1997·Cephalalgia : an International Journal of Headache·S SorianiP Montagna
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J D Rothstein
Apr 9, 2009·Anesthesiology·Ashraf A DahabaHelfried Metzler
Jan 20, 1989·Klinische Wochenschrift·U Klotz
Dec 17, 2008·Metabolic Brain Disease·M BaraldiM L Zeneroli
Jul 10, 2019·Pharmacology & Therapeutics·Marie-Christine TononJérôme Leprince
Oct 12, 1990·Journal of Chromatography·I M Kapetanovic

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