Detection of drug risks after approval : Methods development for the use of routine statutory health insurance data

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Ronja ForaitaI Pigeot

Abstract

Adverse drug reactions are among the leading causes of death. Pharmacovigilance aims to monitor drugs after they have been released to the market in order to detect potential risks. Data sources commonly used to this end are spontaneous reports sent in by doctors or pharmaceutical companies. Reports alone are rather limited when it comes to detecting potential health risks. Routine statutory health insurance data, however, are a richer source since they not only provide a detailed picture of the patients' wellbeing over time, but also contain information on concomitant medication and comorbidities.To take advantage of their potential and to increase drug safety, we will further develop statistical methods that have shown their merit in other fields as a source of inspiration. A plethora of methods have been proposed over the years for spontaneous reporting data: a comprehensive comparison of these methods and their potential use for longitudinal data should be explored. In addition, we show how methods from machine learning could aid in identifying rare risks. We discuss these so-called enrichment analyses and how utilizing pharmaceutical similarities between drugs and similarities between comorbidities could help to construct ...Continue Reading

References

Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Aug 11, 1998·European Journal of Clinical Pharmacology·A BateR M De Freitas
Jan 23, 1999·Clinical Therapeutics·S A Goldman
Nov 23, 2000·Lancet·U A Meyer
Nov 17, 2001·JAMA : the Journal of the American Medical Association·K A PhillipsW Sadee
May 10, 2002·Pharmacoepidemiology and Drug Safety·Eugène P van PuijenbroekAntoine C G Egberts
Feb 22, 2003·Journal of the American Medical Informatics Association : JAMIA·David W BatesGeorge Hripcsak
May 12, 2005·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·I Pigeot, J Windeler
Oct 13, 2005·Statistics in Medicine·Heather J WhitakerPatrick Musonda
Oct 5, 2006·Pharmacoepidemiology and Drug Safety·Wendy P Stephenson, Manfred Hauben
Feb 9, 2007·Nature Biotechnology·Michael J KeiserBrian K Shoichet
Apr 11, 2009·Statistics in Medicine·Ismaïl AhmedPascale Tubert-Bitter
May 3, 2012·Clinical Pharmacology and Therapeutics·R HarpazC Friedman
Jan 1, 2012·Pharmaceutics·Marc Suling, Iris Pigeot
Mar 22, 2014·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Muaed Jamal Alomar
Mar 31, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jacoline C BouvyMarc A Koopmanschap
Jun 11, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Michael A Mooney, Beth Wilmot
Jun 21, 2015·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Edeltraut Garbe, Iris Pigeot
Nov 22, 2015·Nucleic Acids Research·Damian SzklarczykMichael Kuhn
Dec 3, 2016·Nucleic Acids Research·Anna GaultonAndrew R Leach
Dec 3, 2016·Nucleic Acids Research·Minoru KanehisaKanae Morishima
Mar 3, 2017·European Journal of Clinical Pharmacology·T J OscanoaAlfonso Carvajal

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Citations

Dec 8, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Sebastian KloseMarkus Schwaninger

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