Detection of dynamic protein complexes through Markov Clustering based on Elephant Herd Optimization Approach

Scientific Reports
R Ranjani RaniA Brindhadevi

Abstract

The accessibility of a huge amount of protein-protein interaction (PPI) data has allowed to do research on biological networks that reveal the structure of a protein complex, pathways and its cellular organization. A key demand in computational biology is to recognize the modular structure of such biological networks. The detection of protein complexes from the PPI network, is one of the most challenging and significant problems in the post-genomic era. In Bioinformatics, the frequently employed approach for clustering the networks is Markov Clustering (MCL). Many of the researches for protein complex detection were done on the static PPI network, which suffers from a few drawbacks. To resolve this problem, this paper proposes an approach to detect the dynamic protein complexes through Markov Clustering based on Elephant Herd Optimization Approach (DMCL-EHO). Initially, the proposed method divides the PPI network into a set of dynamic subnetworks under various time points by combining the gene expression data and secondly, it employs the clustering analysis on every subnetwork using the MCL along with Elephant Herd Optimization approach. The experimental analysis was employed on different PPI network datasets and the proposed m...Continue Reading

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Software Mentioned

RNSC
ORGANISM
MCl
FOCA
ACO
BiCAMWI
Windows
CMC
COACH
CFinder

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