Detection of early glaucoma with optical coherence tomography (StratusOCT)

Journal of Glaucoma
Kouros Nouri-MahdaviJoseph Caprioli

Abstract

To evaluate the performance of optical coherence tomography (StratusOCT) for discriminating eyes with early glaucoma from normal eyes. Thirty eyes with established early glaucomatous visual field defects (EGVF group), 30 eyes with evidence of early glaucomatous optic neuropathy with normal standard achromatic perimetry [early glaucoma by disc (EGD)], and 33 age-matched normal eyes with good quality StratusOCT nerve fiber layer (NFL) images were enrolled. Average NFL thickness and NFL thickness at quadrants and sectors, areas under receiver operator characteristic curves, and sensitivities at 80% and 90% specificity were evaluated. The average (+/-SD) mean deviation in the EGVF group was -3.4 (+/-1.7) dB. Receiver operator characteristic curves showed areas under the curve (AUC) for NFL thickness in the superior quadrant (AUC=0.75+/-0.07) and in the inferior quadrant (AUC=0.94+/-0.03) to be the best StratusOCT parameters for discrimination of normal controls from EGD and EGVF eyes, respectively. The best parameter for detection of EGD eyes at 80% and 90% specificities was NFL thickness at superior quadrant (51% and 36% sensitivities, respectively). The best parameter for detection of EGVF eyes at 80% and 90% specificities was NF...Continue Reading

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Citations

Nov 26, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Songfeng LiNingli Wang
Oct 16, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Barbara Cvenkel, Alenka Sket Kontestabile
Sep 20, 2011·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hsin-Yi ChenHsien-Yuan Lane
Oct 30, 2010·The British Journal of Ophthalmology·Kyung Rim SungJoel S Schuman
Dec 26, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kuo-Chi HungMei-Ching Teng
Dec 25, 2009·Ophthalmology·Gisèle LiPaul Harasymowycz
Dec 2, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Mitra SehiDavid S Greenfield
Jun 5, 2012·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Allison K UngarJoel S Schuman
Feb 11, 2012·Korean Journal of Ophthalmology : KJO·Jung Taeck HongMichael S Kook
Jun 13, 2015·The Open Ophthalmology Journal·Carolina P B GracitelliFelipe A Medeiros
Jan 26, 2021·Medical Journal, Armed Forces India·Sanjay Kumar Dhar Abhijit

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