PMID: 9444332Jan 1, 1997Paper

Detection of EBV RNA (EBER-1 and EBER-2) in malaria lymph nodes by in situ hybridization

Microbiology and Immunology
C Facer, G Khan

Abstract

Acute Plasmodium falciparum malaria in African children allows expansion of latent Epstein-Barr virus infection, leading to colonization of lymph nodes by virus-infected lymphoblasts in 60% of cases as demonstrated by in situ hybridization for the detection of EBER-1 and EBER-2 RNA. This probably arises against a background of malaria-induced immunosuppression to EBV and concurrent lymphoid activation. The relevance of the results to the pathogenesis of African endemic Burkitt's lymphoma is discussed.

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M SchwemmleM Bachmann
Jan 1, 1990·Advances in Cancer Research·I Magrath
Jan 1, 1989·Advances in Cancer Research·C A Facer, J H Playfair
Nov 1, 1994·The Journal of Pathology·G Khan, P J Coates
Aug 31, 1996·Lancet·T F SchulzR A Weiss
Jan 1, 1996·Advances in Experimental Medicine and Biology·J GordonJ D Pound

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