Detection of Ehrlichia canis, Babesia vogeli, and Toxoplasma gondii DNA in the Brain of Dogs Naturally Infected with Leishmania infantum

The Journal of Parasitology
Cynthya B CardinotMary Marcondes

Abstract

The aims of this study were to investigate the presence of Leishmania infantum and possible co-infection with Anaplasma platys , Babesia vogeli, Ehrlichia canis , and Toxoplasma gondii in the brain of 24 dogs naturally infected by L. infantum . A total of 24 mongrel adult dogs (22 clinically affected, 2 with neurological signs, and 2 subclinically infected) aged between 2 and 5 yr, naturally infected by visceral leishmaniasis, were selected. Fragments from meninges, frontal cortex, thalamus, cerebellum, and choroid plexus of the lateral ventricles and fourth ventricle were collected, mixed, and tested by real-time polymerase chain reaction (qPCR). Leishmania infantum DNA was detected in 95.8% (23/24) of the infected dogs, including the subclinically infected. A total of 14/24 (58.3%) dogs were co-infected by E. canis and L. infantum , 4/24 (16.7%) were co-infected by E. canis , B. vogeli, and L. infantum , 2/24 (8.3%) were co-infected by B. vogeli and L. infantum , and 1/24 (4.2%) dog was co-infected by E. canis , B. vogeli, T. gondii , and L. infantum . All 24 brain samples tested negative for A. platys . These results demonstrate that L. infantum is able to penetrate into the brain parenchyma, either alone or in association t...Continue Reading

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Citations

Mar 21, 2018·Parasites & Vectors·Marta BaxariasLaia Solano-Gallego
Sep 14, 2019·Journal of the American Veterinary Medical Association·Alba Farré MarinéAlejandro Luján Feliu-Pascual
Mar 14, 2019·Frontiers in Veterinary Science·Rafael Calero-Bernal, Solange M Gennari
Mar 18, 2020·Journal of the American Animal Hospital Association·Wade BurtonMichael Joseph Coyne
Nov 8, 2020·Veterinary Parasitology·Jitender P DubeyChunlei Su

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Methods Mentioned

BETA
biopsy
ELISA
PCR

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