PMID: 9179924May 1, 1997Paper

Detection of elastin in the human fetal membranes: proposed molecular basis for elasticity

Placenta
A D HieberG D Bryant-Greenwood

Abstract

The human fetal membranes provide a sterile biomechanical container which adjust by growth to mid-pregnancy to the increase in fetal size, and by elasticity to the forceful movements of the fetus. The molecular basis for this elasticity is not known, yet reduced elasticity may lead to their premature rupture and preterm birth, a major problem in perinatal medicine. Classically, elastin confers the property of elastic recoil to elastic fibres which are assembled from a family of tropoelastin precursors. These are covalently cross-linked to form insoluble elastin by formation of desmosine and isodesmosine, catalysed by the enzyme lysyl oxidase. The amnion, chorion and decidua were shown by Northern analysis and RT-PCR to contain detectable levels of tropoelastin mRNA and the mRNA encoding lysyl oxidase. The proteins encoded by these mRNAs were also identified by Western blotting and immunolocalization. Further, insoluble elastin was extracted from the human fetal membranes and shown by comparison to elastin preparations from other elastic tissues to have a reasonable desmosine content. Finally, scanning electron microscopy confirmed the presence of multiple layers of an apparently very thin elastic system in this tissue. This bio...Continue Reading

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Citations

Sep 14, 2012·Biomechanics and Modeling in Mechanobiology·W BuerzleE Mazza
Jan 29, 2000·American Journal of Obstetrics and Gynecology·L K MillarG Bryant-Greenwood
Sep 7, 2011·Annales de dermatologie et de vénéréologie·H TauzinP Muret
Mar 14, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mahmood JabareenEdoardo Mazza
Aug 26, 2009·International Journal of Dermatology·Venetia Lo, Elena Pope
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May 23, 2015·Medical Hypotheses·Hassan NiknejadMona Kakavand
Sep 5, 2015·Advances in Wound Care·Jonathan N Brantley, Thomas D Verla
Jul 23, 2014·Tissue Engineering. Part a·Stephan RouxHelene Rouard
Sep 15, 2005·American Journal of Obstetrics and Gynecology·Aleksandr FuksChaur-Dong Hsu
May 21, 2014·Reproductive Sciences·Sophia M R LannonKristina M Adams Waldorf
Feb 8, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·B R HelmigN Uldbjerg
Nov 25, 2000·Biology of Reproduction·G D Bryant-Greenwood, L K Millar
Jun 28, 2020·Journal of Tissue Engineering and Regenerative Medicine·Annelise Roy, Sarah Griffiths
Mar 25, 2018·Stem Cells Translational Medicine·Tor Paaske UtheimAmer Sehic

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