PMID: 6536825Oct 1, 1984Paper

Detection of endothelium in cerebral blood vessels

Journal of Pharmacological Methods
R P AbrolD A Cook

Abstract

An increasing body of evidence implies that the results of pharmacological studies of blood vessels may depend on the presence of an intact layer of endothelial cells inside the blood vessels. This is often inadvertently removed during the early part of the experiment and it is thus necessary to have some means of determining whether the endothelium is intact or has suffered extensive damage. Previous reports describe a stain that will enable the endothelial cells to be visualized, however we find that in the cerebral vasculature this approach is unsatisfactory in that it provides a gross underestimate of the amount of intact endothelium. A modification of the original procedure is described that provides results that correspond well with those of scanning or transmission electron microscopy.

References

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Citations

Aug 29, 1991·European Journal of Pharmacology·M Yamazaki, N Toda
Apr 21, 1994·European Journal of Pharmacology·A JovanovićI Tulić
Apr 1, 1988·Journal of Pharmacological Methods·K NakatsuG S Marks
May 1, 1995·Pharmacology & Therapeutics·D A Cook
Aug 22, 2001·Peptides·M Cardell, L O Cardell
Mar 1, 1997·British Journal of Pharmacology·L O CardellR Uddman
Mar 4, 1998·British Journal of Pharmacology·V N Mutafova-Yambolieva, D P Westfall
Apr 1, 1991·British Journal of Pharmacology·N TodaT Okamura
Feb 1, 1992·British Journal of Pharmacology·L O CardellL Edvinsson
Nov 25, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S PesićI Ilić
Oct 1, 1989·British Journal of Pharmacology·E PipiliM E Maragoudakis
Oct 25, 2016·The Journal of Thoracic and Cardiovascular Surgery·Takeshi KinoshitaTomio Okamura
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K Ayajiki, N Toda
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H OnoueN Nakamura
Jan 24, 2017·The Annals of Thoracic Surgery·Takeshi KinoshitaTomio Okamura
Nov 1, 1988·Stroke; a Journal of Cerebral Circulation·H OnoueN Toda
Dec 22, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·S PesićZ Cvetković
Dec 15, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi KinoshitaTomio Okamura

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