Detection of enterovirus-specific RNA sequences in explanted myocardium biopsy specimens from patients with dilated or ischemic cardiomyopathy

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
L AndreolettiD Hober

Abstract

Enteroviral RNA (EV-RNA) was detected in endomyocardial tissue by means of retrotranscription and polymerase chain reaction (RT-PCR) followed by slot-blot hybridization. The myocardial biopsy specimens studied were taken at the time of heart transplantation from 15 patients with dilated cardiomyopathy (DCM) and from 10 patients with ischemic cardiomyopathy (ICM). Specimens from 18 (72%) of the 25 patients were positive for EV-RNA, whereas no control specimens (myocardial specimens from 29 healthy organ donors and atrial specimens from 15 patients with acute myocardial infarction treated by anatomic bypass) yielded evidence of EV-RNA. The rates of EV-RNA detection for the two groups requiring heart transplantation did not differ significantly (66.7% vs. 80.0%; chi 2 test). Our findings support a link between enteroviral infection in both DCM and ICM and suggest a pathogenic role for the enteroviruses.

Citations

Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Antigoni Triantafyllopoulou, Haralampos Moutsopoulos
Mar 1, 1997·Pathologie-biologie·K Schwartz
Jul 18, 2002·Seminars in Pediatric Infectious Diseases·Mark H Sawyer
Jul 15, 2005·Annals of the New York Academy of Sciences·Antigoni Triantafyllopoulou, Haralampos M Moutsopoulos
Aug 3, 2013·Seminars in Nuclear Medicine·Paola A ErbaGiuliano Mariani
Jul 18, 2002·Dermatologic Clinics·Jennifer R Stalkup, Suneel Chilukuri
Dec 23, 1999·The Pediatric Infectious Disease Journal·M H Sawyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.