PMID: 9650697Jul 3, 1998Paper

Detection of Epstein-Barr virus and HTLV-I in T-cell lymphomas of skin in Taiwan

The American Journal of Dermatopathology
Y T ChangK C Chow

Abstract

Viral etiology has been associated with the pathogenesis of T-cell lymphomas of skin (TCLS). Therefore, we studied the presence of Epstein-Barr virus (EBV) and type I human T-cell lymphotropic virus (HTLV-I) in tumor cells of TCLS to determine the significance of these viruses with the disease. A retrospective study was conducted on the skin tissues from 28 Chinese patients with TCLS. We used in situ hybridization, immunohistochemistry, and polymerase chain reaction to determine the presence of viruses. Among the 28 cases, HTLV-I was only detected in two cases with adult T-cell leukemia/lymphoma, not in other cases of TCLS. This suggests that HTLV-I may not play a significant role in the oncogenesis of TCLS in Chinese patients. Conversely, EBV was detected in 12 cases (42.9%), including the secondary TCLS, large cell lymphoma, mycosis fungoides, adult T-cell leukemia/lymphoma, and angiocentric lymphoma. Nevertheless, latent membrane protein 1 was not detected in any of the EBV-positive cases. Neither was any correlation found between the presence of EBV in TCLS and the prognosis or the severity of the skin lesion. Although there is a close association of EBV with a portion of TCLS, its pathogenic role needs further investigation.

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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·M ShimakageT Kozuka
Jan 5, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·E ErkekA Gököz
Jan 19, 2005·The Journal of Investigative Dermatology·A C KnolB Dreno
Oct 26, 2005·Journal of the American Academy of Dermatology·Anne-Chantal KnolBrigitte Dreno
Jun 30, 2015·Indian Journal of Dermatology·Yalda NahidiMitra Hesamifard
Mar 18, 2008·Lancet·Sam T HwangWyndham H Wilson

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