PMID: 11908874Mar 23, 2002Paper

Detection of Epstein-Barr virus DNA and expression of CD30 antigen in primary anaplastic diffuse large B-cell lymphoma of the brain

Brain Tumor Pathology
T ShimuraM Kawamoto

Abstract

We describe a case of primary anaplastic diffuse large-cell lymphoma arising in the central nervous system (CNS). Primary CD30-positive anaplastic diffuse large B-cell lymphoma of the brain is very rarely reported. Given that this tumor is immunohistochemically heterogeneous, polymerase chain reaction (PCR) and Epstein-Barr virus (EBV) analysis of tumor DNA are essential techniques for early and accurate histological diagnosis in these CD30-positive cerebral lymphoma cases. We report an early CD30- and EBV-positive anaplastic diffuse large B-cell lymphoma in the CNS that was diagnosed not only from the immunohistochemical study and MRI findings, but also from the genotype confirmations. This tumor was documented to have EBV episomes of monoclonal origin by PCR analysis of immunoglobulin gene rearrangement.

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·K A Jellinger, W Paulus
Feb 6, 1988·Lancet·A G StansfeldO Mioduszewska
Apr 1, 1995·American Journal of Clinical Pathology·N HavliogluL Grosso
Nov 1, 1994·Human Pathology·W PaulusH K Müller-Hermelink
Sep 1, 1994·American Journal of Clinical Pathology·G H SegalS L Perkins
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R LaiR W Coupland

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Citations

Jul 2, 2011·Journal of Neuro-oncology·Alexander KofmanRoger Abounader
Mar 28, 2017·Journal of Cutaneous Pathology·Ryanne A BrownJinah Kim

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