PMID: 8948618Dec 1, 1996Paper

Detection of Epstein-Barr virus in salivary gland specimens from Sjögren's syndrome patients

The Laryngoscope
M E Merne, S Syrjänen

Abstract

The cause of Sjögren's syndrome remains unclear, but several environmental and genetic factors have been implicated. The Epstein-Barr virus (EBV), among others (e.g., cytomegalovirus, human herpesvirus 6, and retroviruses), has been widely studied in connection with Sjögren's syndrome without conclusive results. To determine the role of EBV infection in patients with Sjögren's syndrome, the presence of EBV deoxyribonucleic acid (DNA) in major and minor salivary gland biopsy specimens was investigated by means of sulfur 35 in situ hybridization and polymerase chain reaction. Additionally, the presence of latent virus proteins EBV latent membrane protein and Epstein-Barr nuclear antigen 2 was analyzed by immunohistochemical methods. Viral DNA, detected by in situ hybridization, was found in 19% of patients with a diagnosis of Sjögren's syndrome and in 3% of controls. All tissues studied were found to be negative for EBV DNA by polymerase chain reaction. EBV latent membrane protein-positive staining was seen in 17% of patients and 22% of control subjects, while Epstein-Barr-positive staining was found in 25% of patients and 39% of controls. The low frequency of EBV DNA detected in the biopsy specimens does not indicate that the vi...Continue Reading

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Citations

Jun 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D T RoweM Green
Sep 30, 2000·Clinical Otolaryngology and Allied Sciences·S SoodC T Pease
Jul 10, 1999·Pathology, Research and Practice·K I KimI Kim
Mar 1, 2005·Journal of Periodontal Research·Işil SaygunJørgen Slots
Oct 19, 2006·Archives of Medical Research·Mario García-CarrascoRicard Cervera
Jun 30, 2006·La Revue de médecine interne·M TrimecheS Korbi
Dec 1, 2002·Modern Rheumatology·M YamamotoE Suematsu
Jan 3, 2001·Clinics in Dermatology·R I FoxM Stern
Jul 7, 2021·Rheumatology and Therapy·Zhiyong Liu, Aichun Chu

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